TY - JOUR
T1 - Understanding mechanisms to promote successful aging in persons living with HIV
AU - Escota, Gerome V.
AU - O'Halloran, Jane A.
AU - Powderly, William G.
AU - Presti, Rachel M.
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2018/1
Y1 - 2018/1
N2 - The mortality rate associated with HIV infection plummeted after the introduction of effective antiretroviral therapy pioneered two decades ago. As a result, HIV-infected people now have life expectancies comparable to that of HIV-uninfected individuals. Despite this, increased rates of osteoporosis, chronic liver disease, and in particular cardiovascular disease have been reported among people living with HIV infection. With the aging HIV-infected population, the burden of these comorbid illnesses may continue to accrue over time. In this paper, we present an overview of the aging HIV-infected population, its epidemiology and the many challenges faced. How to define and measure successful aging will also be reviewed. Finally, opportunities that may help mitigate the challenges identified and ensure successful aging among people living with HIV infection will be examined.
AB - The mortality rate associated with HIV infection plummeted after the introduction of effective antiretroviral therapy pioneered two decades ago. As a result, HIV-infected people now have life expectancies comparable to that of HIV-uninfected individuals. Despite this, increased rates of osteoporosis, chronic liver disease, and in particular cardiovascular disease have been reported among people living with HIV infection. With the aging HIV-infected population, the burden of these comorbid illnesses may continue to accrue over time. In this paper, we present an overview of the aging HIV-infected population, its epidemiology and the many challenges faced. How to define and measure successful aging will also be reviewed. Finally, opportunities that may help mitigate the challenges identified and ensure successful aging among people living with HIV infection will be examined.
KW - AIDS
KW - Aging
KW - HIV
KW - Successful aging
UR - http://www.scopus.com/inward/record.url?scp=85035750038&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2017.11.010
DO - 10.1016/j.ijid.2017.11.010
M3 - Review article
C2 - 29154830
AN - SCOPUS:85035750038
SN - 1201-9712
VL - 66
SP - 56
EP - 64
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -