Unconventional recognition of peptides by T cells and the implications for autoimmunity

James F. Mohan; Emil R. Unanue

doi:10.1038/nri3294

Unconventional recognition of peptides by T cells and the implications for autoimmunity

James F. Mohan, Emil R. Unanue

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Abstract

The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide-MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune response to proteins. Importantly, these unconventional T cells can be found in the setting of autoimmunity. Here, we discuss unconventional peptide recognition by type B T cells and consider the implications for type 1 diabetes and other autoimmune diseases.

Original language	English
Pages (from-to)	721-728
Number of pages	8
Journal	Nature Reviews Immunology
Volume	12
Issue number	10
DOIs	https://doi.org/10.1038/nri3294
State	Published - Oct 2012

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title = "Unconventional recognition of peptides by T cells and the implications for autoimmunity",

abstract = "The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide-MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune response to proteins. Importantly, these unconventional T cells can be found in the setting of autoimmunity. Here, we discuss unconventional peptide recognition by type B T cells and consider the implications for type 1 diabetes and other autoimmune diseases.",

author = "Mohan, \{James F.\} and Unanue, \{Emil R.\}",

note = "Funding Information: We are grateful to our many colleagues who contributed to the work cited here. They include B. Calderon, J. Carrero, K. Chang, M. Gross, J. Herzog, M. Levisetti, S. Lovitch, M. Miller, S. Petzold, Z. Pu and B. Strong. Our work was supported by grants from the US National Institutes of Health, the Juvenile Diabetes Research Foundation and the Kilo Diabetes and Vascular Research Foundation.",

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AU - Unanue, Emil R.

N1 - Funding Information: We are grateful to our many colleagues who contributed to the work cited here. They include B. Calderon, J. Carrero, K. Chang, M. Gross, J. Herzog, M. Levisetti, S. Lovitch, M. Miller, S. Petzold, Z. Pu and B. Strong. Our work was supported by grants from the US National Institutes of Health, the Juvenile Diabetes Research Foundation and the Kilo Diabetes and Vascular Research Foundation.

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N2 - The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide-MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune response to proteins. Importantly, these unconventional T cells can be found in the setting of autoimmunity. Here, we discuss unconventional peptide recognition by type B T cells and consider the implications for type 1 diabetes and other autoimmune diseases.

AB - The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide-MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune response to proteins. Importantly, these unconventional T cells can be found in the setting of autoimmunity. Here, we discuss unconventional peptide recognition by type B T cells and consider the implications for type 1 diabetes and other autoimmune diseases.

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DO - 10.1038/nri3294

M3 - Review article

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JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

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Unconventional recognition of peptides by T cells and the implications for autoimmunity

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