While there is increasing interest in PTA as a disease process, the area is relatively unstudied. In many cases joint injuries are managed mainly by orthopedic surgeons. Orthopedic surgeons have used surgical management as the primary (and often only) form of treatment to prevent PTA after joint injury. In part this is because no pharmacologic therapies are currently available to limit PTA development after joint injury. Several new lines of research indicate that there may be opportunities to modulate the post-injury response to limit the development of PTA. Still there are key areas of knowledge that need to be addressed. These are: (1) Who is at risk to develop PTA? (2) How do we follow disease progression of PTA? (3) How do we effectively modify the response to joint injury to prevent PTA? and (4) What is the effect of surgical repair on the post-injury response?

Original languageEnglish
Title of host publicationPost-Traumatic Arthritis
Subtitle of host publicationPathogenesis, Diagnosis and Management
PublisherSpringer US
Number of pages4
ISBN (Electronic)9781489976062
ISBN (Print)9781489976055
StatePublished - Jan 1 2015


  • Disease progression
  • Joint injury
  • Post-injury response
  • Post-traumatic arthritis
  • Prevention


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