@inproceedings{b2872d15a9e54d6691f0aafd3622ae48,
title = "Ultrasonic molecular imaging of primordial angiogenic vessels in rabbit and mouse models with αvβ3-integrin targeted nanoparticles using information-theoretic signal detection: Results at high frequency and in the clinical diagnostic frequency range",
abstract = "The objective of this study was to assess the feasibility of image-based identification of nanoparticle targeted angiogenic neovasculature using backscattered ultrasound in several frequency ranges (7 to 15 and ∼20-35MHz). We employed a liquid-perfluorocarbon nanoparticle contrast agent to target the expression of αvβ3 in tumors implanted two different animal models. Ten K14-HPV16 transgenic mice were treated with either normal saline (n=5) or 0.3 mg/kg i.V. of αvβ3-targeted nanoparticles (n=5) and imaged dynamically for two hours using a research ultrasound imager (Vevo 660 30MHz probe) modified to store digitized RF waveforms. Data were analyzed for all mice at all times post-injection using conventional grayscale and HC (an information-theoretic quantity). These data demonstrate the ability and complementarity of information-theoretic receivers in conjunction with targeted nanoparticles to elucidate the presence of αvβ 3-integrins in primordial neovasculature, particularly in acoustically unfavorable environments.",
author = "M. Hughes and Marsh, \{J. N.\} and Jeffrey Arbeit and Robert Neumann and Fuhrhop, \{R. W.\} and Lanza, \{G. M.\} and Wickline, \{S. A.\}",
year = "2005",
doi = "10.1109/ULTSYM.2005.1602928",
language = "English",
isbn = "0780393821",
series = "Proceedings - IEEE Ultrasonics Symposium",
pages = "617--620",
booktitle = "2005 IEEE Ultrasonics Symposium",
note = "2005 IEEE Ultrasonics Symposium ; Conference date: 18-09-2005 Through 21-09-2005",
}