Ultrasonic molecular imaging of primordial angiogenic vessels in rabbit and mouse models with αvβ3-integrin targeted nanoparticles using information-theoretic signal detection: Results at high frequency and in the clinical diagnostic frequency range

M. Hughes, J. N. Marsh, Jeffrey Arbeit, Robert Neumann, R. W. Fuhrhop, G. M. Lanza, S. A. Wickline

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

12 Scopus citations

Abstract

The objective of this study was to assess the feasibility of image-based identification of nanoparticle targeted angiogenic neovasculature using backscattered ultrasound in several frequency ranges (7 to 15 and ∼20-35MHz). We employed a liquid-perfluorocarbon nanoparticle contrast agent to target the expression of αvβ3 in tumors implanted two different animal models. Ten K14-HPV16 transgenic mice were treated with either normal saline (n=5) or 0.3 mg/kg i.V. of αvβ3-targeted nanoparticles (n=5) and imaged dynamically for two hours using a research ultrasound imager (Vevo 660 30MHz probe) modified to store digitized RF waveforms. Data were analyzed for all mice at all times post-injection using conventional grayscale and HC (an information-theoretic quantity). These data demonstrate the ability and complementarity of information-theoretic receivers in conjunction with targeted nanoparticles to elucidate the presence of αvβ 3-integrins in primordial neovasculature, particularly in acoustically unfavorable environments.

Original languageEnglish
Title of host publication2005 IEEE Ultrasonics Symposium
Pages617-620
Number of pages4
DOIs
StatePublished - 2005
Event2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands
Duration: Sep 18 2005Sep 21 2005

Publication series

NameProceedings - IEEE Ultrasonics Symposium
Volume1
ISSN (Print)1051-0117

Conference

Conference2005 IEEE Ultrasonics Symposium
Country/TerritoryNetherlands
CityRotterdam
Period09/18/0509/21/05

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