TY - JOUR
T1 - Ultrasmall nanoclusters
T2 - Synthesis and applications as an emerging platform for imaging and therapy
AU - Zhang, Xiaohui
AU - Sultan, Deborah
AU - Heo, Gyu Seong
AU - Luehmann, Hannah
AU - Detering, Lisa
AU - Liu, Yongjian
N1 - Funding Information:
This work is supported by NHLBI.
Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021
Y1 - 2021
N2 - Background: Ultrasmall nanoclusters (USNCs) have attracted tremendous attention owing to their unique properties that make them desirable for the development of personalized medicine, such as tunable emission, straightforward modification, and renal clearance. Hence, USNCs have emerged as potential materials for nanotheranostics. Objective: For decades, great efforts have been devoted to the bio-applications of USNCs, promising platforms to satisfy the increasing demand for precise diagnostic and targeted therapeutics. Herein, we summarize the most recent advances of USNCs in biomedical applications and provide our perspective on the future development of USNCs. Results: This review briefly summarized the synthetic methods of metallic USNCs and discussed their recent applications for cancer imaging and therapy. Conclusion: USNCs have shown their potential for accurate diagnosis and specific delivery of therapeutics in preclinical research.
AB - Background: Ultrasmall nanoclusters (USNCs) have attracted tremendous attention owing to their unique properties that make them desirable for the development of personalized medicine, such as tunable emission, straightforward modification, and renal clearance. Hence, USNCs have emerged as potential materials for nanotheranostics. Objective: For decades, great efforts have been devoted to the bio-applications of USNCs, promising platforms to satisfy the increasing demand for precise diagnostic and targeted therapeutics. Herein, we summarize the most recent advances of USNCs in biomedical applications and provide our perspective on the future development of USNCs. Results: This review briefly summarized the synthetic methods of metallic USNCs and discussed their recent applications for cancer imaging and therapy. Conclusion: USNCs have shown their potential for accurate diagnosis and specific delivery of therapeutics in preclinical research.
KW - Cancer
KW - Imaging
KW - Medicine
KW - Nanotheranostics
KW - Therapy
KW - Ultrasmall nanocluster
UR - http://www.scopus.com/inward/record.url?scp=85100870479&partnerID=8YFLogxK
U2 - 10.2174/1573411016666191230151648
DO - 10.2174/1573411016666191230151648
M3 - Article
AN - SCOPUS:85100870479
SN - 1573-4110
VL - 17
SP - 287
EP - 301
JO - Current Analytical Chemistry
JF - Current Analytical Chemistry
IS - 3
ER -