Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology

Tsung Han Tsai, Benjamin Potsaid, Yuankai K. Tao, Vijaysekhar Jayaraman, James Jiang, Peter J.S. Heim, Martin F. Kraus, Chao Zhou, Joachim Hornegger, Hiroshi Mashimo, Alex E. Cable, James G. Fujimoto

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

We developed a micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surfaceemitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT imaging in the rabbit GI tract and ex vivo imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated.

Original languageEnglish
Pages (from-to)1119-1132
Number of pages14
JournalBiomedical Optics Express
Volume4
Issue number7
DOIs
StatePublished - 2013

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