Ultrafast MR imaging of water mobility: Animal models of altered cerebral perfusion

Robert C. McKinstry, Robert M. Weiskoff, John W. Belliveau, James M. Vevea, John B. Moore, Kenneth W. Kwong, Elkan F. Halpern, Bruce R. Rosen

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

“Single shot” magnetic resonance (MR) diffusion imaging was used to study the details of signal decay curves in experimental perturbations of cerebral perfusion induced by hypercapnia or death. Despite large perfusion increases observed with dynamic susceptibility‐contrast MR imaging, no correlation with these changes was seen in either the diffusion coefficient or any other intravoxel incoherent motion (IVIM) model parameters in dog gray matter as arterial carbon dioxide pressure increased. Non‐monoexponential signal decay in cat gray matter was seen both before and after death. In addition, cat gray matter demonstrated a steady decrease in the diffusion coefficient after death. These data are strong evidence that the fast component of the non‐monoexponential diffusion‐related signal decay is not due solely to perfusion. The authors believe that a second compartment of nonex‐changing spins, most likely cerebrospinal fluid, accounts for the non‐monoexponential decay.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume2
Issue number4
DOIs
StatePublished - 1992

Keywords

  • Brain, MR, 10.1214
  • Brain, perfusion
  • Cerebral blood vessels, flow dynamics
  • Cerebral blood vessels. MR, 17.1214
  • Diffusion imaging
  • Echo‐planar imaging
  • Rapid imaging

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