Ubiquitin—a beacon for all during quality control on the ribosome

Liewei L. Yan; Hani S. Zaher

doi:10.15252/embj.2019101633

Ubiquitin—a beacon for all during quality control on the ribosome

Liewei L. Yan, Hani S. Zaher

Research output: Contribution to journal › Comment/debate

4 Scopus citations

Abstract

Ribosome stalling triggers no-go decay (NGD) and ribosome-associated quality control (RQC) pathways to rapidly degrade the aberrant mRNA and the incomplete nascent peptide, respectively. Two recent studies in yeast and mammalian systems reveal the importance of stalling-induced ribosomal protein ubiquitination by Hel2/ZNF598 for both NGD and RQC. The studies also structurally explain how collided ribosomes generate a unique interface not present in monosomes, which can be recognized by Hel2/ZNF598 ubiquitin ligases.

Original language	English
Article number	e101633
Journal	EMBO Journal
Volume	38
Issue number	5
DOIs	https://doi.org/10.15252/embj.2019101633
State	Published - Mar 1 2019

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abstract = "Ribosome stalling triggers no-go decay (NGD) and ribosome-associated quality control (RQC) pathways to rapidly degrade the aberrant mRNA and the incomplete nascent peptide, respectively. Two recent studies in yeast and mammalian systems reveal the importance of stalling-induced ribosomal protein ubiquitination by Hel2/ZNF598 for both NGD and RQC. The studies also structurally explain how collided ribosomes generate a unique interface not present in monosomes, which can be recognized by Hel2/ZNF598 ubiquitin ligases.",

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AU - Zaher, Hani S.

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AB - Ribosome stalling triggers no-go decay (NGD) and ribosome-associated quality control (RQC) pathways to rapidly degrade the aberrant mRNA and the incomplete nascent peptide, respectively. Two recent studies in yeast and mammalian systems reveal the importance of stalling-induced ribosomal protein ubiquitination by Hel2/ZNF598 for both NGD and RQC. The studies also structurally explain how collided ribosomes generate a unique interface not present in monosomes, which can be recognized by Hel2/ZNF598 ubiquitin ligases.

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ER -

Ubiquitin—a beacon for all during quality control on the ribosome

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