Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2

Aaron M. Ver Heul; C. Andrew Fowler; S. Ramaswamy; Robert C. Piper

doi:10.1074/jbc.M112.413781

Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2

Aaron M. Ver Heul
, C. Andrew Fowler
, S. Ramaswamy
, Robert C. Piper

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Background: NOD1 and NOD2 are innate immune receptors implicated in inflammatory diseases. Results: The CARDs ofNOD1andNOD2bind ubiquitin; mutations that block this interaction increase inflammatory signaling. Conclusion: NOD1 and NOD2 signaling is regulated in part by interaction of their CARDs with ubiquitin. Significance: Understanding the regulatory mechanisms of NOD1 and NOD2 is crucial to defining their role in inflammation.

Original language	English
Pages (from-to)	6890-6902
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M112.413781
State	Published - Mar 8 2013

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title = "Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2",

abstract = "Background: NOD1 and NOD2 are innate immune receptors implicated in inflammatory diseases. Results: The CARDs ofNOD1andNOD2bind ubiquitin; mutations that block this interaction increase inflammatory signaling. Conclusion: NOD1 and NOD2 signaling is regulated in part by interaction of their CARDs with ubiquitin. Significance: Understanding the regulatory mechanisms of NOD1 and NOD2 is crucial to defining their role in inflammation.",

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T1 - Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2

AU - Ver Heul, Aaron M.

AU - Fowler, C. Andrew

AU - Ramaswamy, S.

AU - Piper, Robert C.

PY - 2013/3/8

Y1 - 2013/3/8

N2 - Background: NOD1 and NOD2 are innate immune receptors implicated in inflammatory diseases. Results: The CARDs ofNOD1andNOD2bind ubiquitin; mutations that block this interaction increase inflammatory signaling. Conclusion: NOD1 and NOD2 signaling is regulated in part by interaction of their CARDs with ubiquitin. Significance: Understanding the regulatory mechanisms of NOD1 and NOD2 is crucial to defining their role in inflammation.

AB - Background: NOD1 and NOD2 are innate immune receptors implicated in inflammatory diseases. Results: The CARDs ofNOD1andNOD2bind ubiquitin; mutations that block this interaction increase inflammatory signaling. Conclusion: NOD1 and NOD2 signaling is regulated in part by interaction of their CARDs with ubiquitin. Significance: Understanding the regulatory mechanisms of NOD1 and NOD2 is crucial to defining their role in inflammation.

UR - https://www.scopus.com/pages/publications/84874857071

U2 - 10.1074/jbc.M112.413781

DO - 10.1074/jbc.M112.413781

M3 - Article

C2 - 23300079

AN - SCOPUS:84874857071

SN - 0021-9258

VL - 288

SP - 6890

EP - 6902

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 10

ER -

Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2

Abstract

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