Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2

Aaron M. Ver Heul, C. Andrew Fowler, S. Ramaswamy, Robert C. Piper

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Background: NOD1 and NOD2 are innate immune receptors implicated in inflammatory diseases. Results: The CARDs ofNOD1andNOD2bind ubiquitin; mutations that block this interaction increase inflammatory signaling. Conclusion: NOD1 and NOD2 signaling is regulated in part by interaction of their CARDs with ubiquitin. Significance: Understanding the regulatory mechanisms of NOD1 and NOD2 is crucial to defining their role in inflammation.

Original languageEnglish
Pages (from-to)6890-6902
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number10
DOIs
StatePublished - Mar 8 2013
Externally publishedYes

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