Abstract
Background: NOD1 and NOD2 are innate immune receptors implicated in inflammatory diseases. Results: The CARDs ofNOD1andNOD2bind ubiquitin; mutations that block this interaction increase inflammatory signaling. Conclusion: NOD1 and NOD2 signaling is regulated in part by interaction of their CARDs with ubiquitin. Significance: Understanding the regulatory mechanisms of NOD1 and NOD2 is crucial to defining their role in inflammation.
Original language | English |
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Pages (from-to) | 6890-6902 |
Number of pages | 13 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 10 |
DOIs | |
State | Published - Mar 8 2013 |