TY - JOUR
T1 - Ubiquitin-mediated protein modification and degradation.
AU - Schwartz, A. L.
AU - Ciechanover, A.
PY - 1992/11
Y1 - 1992/11
N2 - Ubiquitin is a small, 8 kD protein found in all eukaryotic cells. It is involved in a wide variety of regulatory roles within the cell, including gene expression, ribosome biosynthesis, receptor expression, and the stress response. The best understood of these is that of ubiquitin-mediated proteolysis, in which ubiquitin is covalently attached to specific protein target substrates that are then recognized and degraded by a high molecular weight protease.
AB - Ubiquitin is a small, 8 kD protein found in all eukaryotic cells. It is involved in a wide variety of regulatory roles within the cell, including gene expression, ribosome biosynthesis, receptor expression, and the stress response. The best understood of these is that of ubiquitin-mediated proteolysis, in which ubiquitin is covalently attached to specific protein target substrates that are then recognized and degraded by a high molecular weight protease.
UR - http://www.scopus.com/inward/record.url?scp=0026955094&partnerID=8YFLogxK
U2 - 10.1165/ajrcmb/7.5.463
DO - 10.1165/ajrcmb/7.5.463
M3 - Review article
C2 - 1329865
AN - SCOPUS:0026955094
SN - 1044-1549
VL - 7
SP - 463
EP - 468
JO - American Journal of Respiratory Cell and Molecular Biology
JF - American Journal of Respiratory Cell and Molecular Biology
IS - 5
ER -