Ubiquitin-mediated protein modification and degradation.

A. L. Schwartz, A. Ciechanover

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Ubiquitin is a small, 8 kD protein found in all eukaryotic cells. It is involved in a wide variety of regulatory roles within the cell, including gene expression, ribosome biosynthesis, receptor expression, and the stress response. The best understood of these is that of ubiquitin-mediated proteolysis, in which ubiquitin is covalently attached to specific protein target substrates that are then recognized and degraded by a high molecular weight protease.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Issue number5
StatePublished - Nov 1992


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