Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C

Kerry S. Campbell, Mark Dessing, Miguel Lopez-Botet, Marina Cella, Marco Colonna

Research output: Contribution to journalArticlepeer-review

195 Scopus citations

Abstract

Natural killer (NK) cells express killer inhibitory receptors that mediate negative regulation of NK cell cytotoxicity upon binding to MHC class I molecules on target cells. Unrelated inhibitory receptors on B cells have recently been shown to function through recruitment of phosphotyrosine phosphatase 1C (PTP-1C). Here, we show that a human killer inhibitory receptor specific for HLA-C also recruits PTP-1C after phosphorylation induced either by the pharmacological agent phenylarsine oxide or by conjugation with target cells. This recruitment is mediated by the binding of specific cytoplasmic phosphotyrosine-containing sequences to PTP-1C. These results implicate PTP-1C as a cytosolic component of the negative signaling pathway through NK cell inhibitory receptors.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalJournal of Experimental Medicine
Volume184
Issue number1
DOIs
StatePublished - Jul 1 1996

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