Tyrosine hydroxylase-like (TH) immunoreactivity in human mesolimbic system

Richard M. Torack; John C. Morris

doi:10.1016/0304-3940(90)90389-Q

Tyrosine hydroxylase-like (TH) immunoreactivity in human mesolimbic system

Richard M. Torack, John C. Morris

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A practical methodology has been described for the use of human postmortem brain tissue in both tyrosine hydroxylase and dopamine β-hydroxylase immunohistochemistry in which in situ perfusion with paraformaldehyde is followed by immersion fixation in Bouin's fixative. These studies indicate that TH-like immunoreactive fibers and terminals are not uniformly distributed in the human hippocampal complex. A distinctive lesser innervation is noted for the structures that compose the perforant pathway and may be important for the predilection of these areas for pathological change particularly as occurs in Alzheimer's disease.

Original language	English
Pages (from-to)	75-80
Number of pages	6
Journal	Neuroscience Letters
Volume	116
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(90)90389-Q
State	Published - Aug 14 1990

Keywords

Alzheimer's disease
Bouin's fixative
Hippocampal complex
Perforant pathway
TH-like immunoreactive fiber
TH-like immunoreactive terminal

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10.1016/0304-3940(90)90389-Q

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title = "Tyrosine hydroxylase-like (TH) immunoreactivity in human mesolimbic system",

abstract = "A practical methodology has been described for the use of human postmortem brain tissue in both tyrosine hydroxylase and dopamine β-hydroxylase immunohistochemistry in which in situ perfusion with paraformaldehyde is followed by immersion fixation in Bouin's fixative. These studies indicate that TH-like immunoreactive fibers and terminals are not uniformly distributed in the human hippocampal complex. A distinctive lesser innervation is noted for the structures that compose the perforant pathway and may be important for the predilection of these areas for pathological change particularly as occurs in Alzheimer's disease.",

keywords = "Alzheimer's disease, Bouin's fixative, Hippocampal complex, Perforant pathway, TH-like immunoreactive fiber, TH-like immunoreactive terminal",

author = "Torack, {Richard M.} and Morris, {John C.}",

note = "Funding Information: The authors wish to thank Janet Chavez for her technical assistance and Sandy Brickey for her help in the preparation of this manuscript. This work was supported by Grant 11RG-87-119 from the Alzheimer Disease and Related Disorders Association.",

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AU - Morris, John C.

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N2 - A practical methodology has been described for the use of human postmortem brain tissue in both tyrosine hydroxylase and dopamine β-hydroxylase immunohistochemistry in which in situ perfusion with paraformaldehyde is followed by immersion fixation in Bouin's fixative. These studies indicate that TH-like immunoreactive fibers and terminals are not uniformly distributed in the human hippocampal complex. A distinctive lesser innervation is noted for the structures that compose the perforant pathway and may be important for the predilection of these areas for pathological change particularly as occurs in Alzheimer's disease.

AB - A practical methodology has been described for the use of human postmortem brain tissue in both tyrosine hydroxylase and dopamine β-hydroxylase immunohistochemistry in which in situ perfusion with paraformaldehyde is followed by immersion fixation in Bouin's fixative. These studies indicate that TH-like immunoreactive fibers and terminals are not uniformly distributed in the human hippocampal complex. A distinctive lesser innervation is noted for the structures that compose the perforant pathway and may be important for the predilection of these areas for pathological change particularly as occurs in Alzheimer's disease.

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KW - Bouin's fixative

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KW - TH-like immunoreactive terminal

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Tyrosine hydroxylase-like (TH) immunoreactivity in human mesolimbic system

Abstract

Keywords

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