Typical and Atypical Neurodevelopment for Face Specialization: An fMRI Study

Jane E. Joseph, Xun Zhu, Andrew Gundran, Faraday Davies, Jonathan D. Clark, Lisa Ruble, Paul Glaser, Ramesh S. Bhatt

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Individuals with autism spectrum disorder (ASD) and their relatives process faces differently from typically developed (TD) individuals. In an fMRI face-viewing task, TD and undiagnosed sibling (SIB) children (5–18 years) showed face specialization in the right amygdala and ventromedial prefrontal cortex, with left fusiform and right amygdala face specialization increasing with age in TD subjects. SIBs showed extensive antero-medial temporal lobe activation for faces that was not present in any other group, suggesting a potential compensatory mechanism. In ASD, face specialization was minimal but increased with age in the right fusiform and decreased with age in the left amygdala, suggesting atypical development of a frontal–amygdala–fusiform system which is strongly linked to detecting salience and processing facial information.

Original languageEnglish
Pages (from-to)1725-1741
Number of pages17
JournalJournal of autism and developmental disorders
Volume45
Issue number6
DOIs
StatePublished - Dec 6 2015
Externally publishedYes

Keywords

  • Autism spectrum disorder
  • Face processing
  • Typical development
  • Undiagnosed siblings
  • fMRI

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    Joseph, J. E., Zhu, X., Gundran, A., Davies, F., Clark, J. D., Ruble, L., Glaser, P., & Bhatt, R. S. (2015). Typical and Atypical Neurodevelopment for Face Specialization: An fMRI Study. Journal of autism and developmental disorders, 45(6), 1725-1741. https://doi.org/10.1007/s10803-014-2330-4