Typical and Atypical Neurodevelopment for Face Specialization: An fMRI Study

Jane E. Joseph; Xun Zhu; Andrew Gundran; Faraday Davies; Jonathan D. Clark; Lisa Ruble; Paul Glaser; Ramesh S. Bhatt

doi:10.1007/s10803-014-2330-4

Typical and Atypical Neurodevelopment for Face Specialization: An fMRI Study

Jane E. Joseph, Xun Zhu, Andrew Gundran, Faraday Davies, Jonathan D. Clark, Lisa Ruble, Paul Glaser, Ramesh S. Bhatt

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15 Scopus citations

Abstract

Individuals with autism spectrum disorder (ASD) and their relatives process faces differently from typically developed (TD) individuals. In an fMRI face-viewing task, TD and undiagnosed sibling (SIB) children (5–18 years) showed face specialization in the right amygdala and ventromedial prefrontal cortex, with left fusiform and right amygdala face specialization increasing with age in TD subjects. SIBs showed extensive antero-medial temporal lobe activation for faces that was not present in any other group, suggesting a potential compensatory mechanism. In ASD, face specialization was minimal but increased with age in the right fusiform and decreased with age in the left amygdala, suggesting atypical development of a frontal–amygdala–fusiform system which is strongly linked to detecting salience and processing facial information.

Original language	English
Pages (from-to)	1725-1741
Number of pages	17
Journal	Journal of autism and developmental disorders
Volume	45
Issue number	6
DOIs	https://doi.org/10.1007/s10803-014-2330-4
State	Published - Dec 6 2015

Keywords

Autism spectrum disorder
Face processing
Typical development
Undiagnosed siblings
fMRI

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10.1007/s10803-014-2330-4

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title = "Typical and Atypical Neurodevelopment for Face Specialization: An fMRI Study",

abstract = "Individuals with autism spectrum disorder (ASD) and their relatives process faces differently from typically developed (TD) individuals. In an fMRI face-viewing task, TD and undiagnosed sibling (SIB) children (5–18 years) showed face specialization in the right amygdala and ventromedial prefrontal cortex, with left fusiform and right amygdala face specialization increasing with age in TD subjects. SIBs showed extensive antero-medial temporal lobe activation for faces that was not present in any other group, suggesting a potential compensatory mechanism. In ASD, face specialization was minimal but increased with age in the right fusiform and decreased with age in the left amygdala, suggesting atypical development of a frontal–amygdala–fusiform system which is strongly linked to detecting salience and processing facial information.",

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note = "Funding Information: This research was sponsored by Autism Speaks and the National Institutes of Health (R01 HD052724, R01 HD042452). We thank Christine Corbly, Myra Huffman and Melissa Wheatley for assistance with data collection and Michelle DiBartolo for help with manuscript preparation. Publisher Copyright: {\textcopyright} 2014, Springer Science+Business Media New York.",

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AU - Ruble, Lisa

AU - Glaser, Paul

AU - Bhatt, Ramesh S.

N1 - Funding Information: This research was sponsored by Autism Speaks and the National Institutes of Health (R01 HD052724, R01 HD042452). We thank Christine Corbly, Myra Huffman and Melissa Wheatley for assistance with data collection and Michelle DiBartolo for help with manuscript preparation. Publisher Copyright: © 2014, Springer Science+Business Media New York.

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Typical and Atypical Neurodevelopment for Face Specialization: An fMRI Study

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