TY - JOUR
T1 - Typical and atypical chronic lymphocytic leukemia differ clinically and immunophenotypically
AU - Frater, John L.
AU - McCarron, Karen F.
AU - Hammel, Jeffrey P.
AU - Shapiro, Joel L.
AU - Miller, Michael L.
AU - Tubbs, Raymond R.
AU - Pettay, James
AU - Hsi, Eric D.
PY - 2001/12/1
Y1 - 2001/12/1
N2 - We compared the features of 17 cases of atypical chronic lymphocytic leukemia (aCLL) with those of a clinical control group of 24 cases of CLL. Quantitative flow cytometric data, available for 12 cases, were compared with an immunophenotypic control group of 58 cases using a relative fluorescence index for CD5, CD23, CD79b, and surface immunoglobulin light chain (sIg). Compared with the clinical control group, patients with aCLL had a higher mean WBC count and a lower platelet count. Patients with aCLL had a significantly higher probability of disease progression. Compared with an immunophenotypic control group of 58 CLL cases, 12 cases of aCLL demonstrated significantly higher expression of CD23. There was no significant difference in expression of sIg, CD79b, or CD5 between the groups. CD38 expression was noted in only 1 (9%) of 11 tested cases; 2 (18%) of 11 cases had trisomy 12. aCLL can be distinguished from typical CLL morphologically, clinically, and immunophenotypically. Atypical morphologic features in CLL seem to be a marker of aggressive clinical behavior.
AB - We compared the features of 17 cases of atypical chronic lymphocytic leukemia (aCLL) with those of a clinical control group of 24 cases of CLL. Quantitative flow cytometric data, available for 12 cases, were compared with an immunophenotypic control group of 58 cases using a relative fluorescence index for CD5, CD23, CD79b, and surface immunoglobulin light chain (sIg). Compared with the clinical control group, patients with aCLL had a higher mean WBC count and a lower platelet count. Patients with aCLL had a significantly higher probability of disease progression. Compared with an immunophenotypic control group of 58 CLL cases, 12 cases of aCLL demonstrated significantly higher expression of CD23. There was no significant difference in expression of sIg, CD79b, or CD5 between the groups. CD38 expression was noted in only 1 (9%) of 11 tested cases; 2 (18%) of 11 cases had trisomy 12. aCLL can be distinguished from typical CLL morphologically, clinically, and immunophenotypically. Atypical morphologic features in CLL seem to be a marker of aggressive clinical behavior.
KW - Atypical chronic lymphocytic leukemia
KW - Chronic lymphocytic leukemia
KW - Flow cytometry
KW - Fluorescence in situ hybridization
KW - Polymerase chain reaction
UR - http://www.scopus.com/inward/record.url?scp=0035736708&partnerID=8YFLogxK
U2 - 10.1309/7Q1J-1AA8-DU4Q-PVLQ
DO - 10.1309/7Q1J-1AA8-DU4Q-PVLQ
M3 - Article
C2 - 11710681
AN - SCOPUS:0035736708
SN - 0002-9173
VL - 116
SP - 655
EP - 664
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 5
ER -