TY - JOUR
T1 - Type IVB secretion by intracellular pathogens
AU - Sexton, Jessica A.
AU - Vogel, Joseph P.
PY - 2002
Y1 - 2002
N2 - A growing number of pathogens are being found to possess specialized secretion systems which they use in various ways to subvert host defenses. One class, called type IV, are defined as having homology to the conjugal transfer systems of naturally occurring plasmids. It has been proposed that pathogens with type IV secretion systems have acquired and adapted the conjugal transfer systems of plasmids and now use them to export toxins. Several well-characterized intracellular pathogens, including Legionella pneumophila, Coxiella burnetii, Brucella abortus, and Rickettsia prowazekii, contain type IV systems which are known or suspected to be of critical importance in their ability to cause disease. Specifically, these systems are believed to be the key factors determining intracellular fate, and thus the ability to replicate and cause disease.
AB - A growing number of pathogens are being found to possess specialized secretion systems which they use in various ways to subvert host defenses. One class, called type IV, are defined as having homology to the conjugal transfer systems of naturally occurring plasmids. It has been proposed that pathogens with type IV secretion systems have acquired and adapted the conjugal transfer systems of plasmids and now use them to export toxins. Several well-characterized intracellular pathogens, including Legionella pneumophila, Coxiella burnetii, Brucella abortus, and Rickettsia prowazekii, contain type IV systems which are known or suspected to be of critical importance in their ability to cause disease. Specifically, these systems are believed to be the key factors determining intracellular fate, and thus the ability to replicate and cause disease.
KW - Conjugation
KW - Coxiella burnetii
KW - Intracellular pathogens
KW - Legionella pneumophila
KW - Type IV secretion systems
UR - http://www.scopus.com/inward/record.url?scp=0036112267&partnerID=8YFLogxK
U2 - 10.1034/j.1600-0854.2002.030303.x
DO - 10.1034/j.1600-0854.2002.030303.x
M3 - Review article
C2 - 11886588
AN - SCOPUS:0036112267
SN - 1398-9219
VL - 3
SP - 178
EP - 185
JO - Traffic
JF - Traffic
IS - 3
ER -