Type i phosphotidylinosotol 4-phosphate 5-kinase regulates osteoclasts in a bifunctional manner

Tingting Zhu, Jean C. Chappe, Fong Fu Hsu, John Turk, Rajeev Aurora, Krzysztof Hyrc, Pietro De Camilli, Thomas J. Broekelmann, Robert P. Mecham, Steven L. Teitelbaum, Wei Zou

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: PI(4,5)P2, mainly synthesized by PIP5KI, is essential for normal cell function. Results: Deficiency or overexpression of PIP5KI, which results in decrease or increase of PI(4,5)P2, respectively, impairs osteoclast differentiation and function. Conclusion: Optimal PIP5KI and PI(4,5)P2 expression are important for osteoclast function. Significance: This is the first demonstration that PIP5KI regulates cells in a bifunctional manner.

Original languageEnglish
Pages (from-to)5268-5277
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013

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