TY - JOUR
T1 - Type i phosphotidylinosotol 4-phosphate 5-kinase regulates osteoclasts in a bifunctional manner
AU - Zhu, Tingting
AU - Chappe, Jean C.
AU - Hsu, Fong Fu
AU - Turk, John
AU - Aurora, Rajeev
AU - Hyrc, Krzysztof
AU - De Camilli, Pietro
AU - Broekelmann, Thomas J.
AU - Mecham, Robert P.
AU - Teitelbaum, Steven L.
AU - Zou, Wei
PY - 2013/2/22
Y1 - 2013/2/22
N2 - Background: PI(4,5)P2, mainly synthesized by PIP5KI, is essential for normal cell function. Results: Deficiency or overexpression of PIP5KI, which results in decrease or increase of PI(4,5)P2, respectively, impairs osteoclast differentiation and function. Conclusion: Optimal PIP5KI and PI(4,5)P2 expression are important for osteoclast function. Significance: This is the first demonstration that PIP5KI regulates cells in a bifunctional manner.
AB - Background: PI(4,5)P2, mainly synthesized by PIP5KI, is essential for normal cell function. Results: Deficiency or overexpression of PIP5KI, which results in decrease or increase of PI(4,5)P2, respectively, impairs osteoclast differentiation and function. Conclusion: Optimal PIP5KI and PI(4,5)P2 expression are important for osteoclast function. Significance: This is the first demonstration that PIP5KI regulates cells in a bifunctional manner.
UR - http://www.scopus.com/inward/record.url?scp=84874287635&partnerID=8YFLogxK
U2 - 10.1074/jbc.M112.446054
DO - 10.1074/jbc.M112.446054
M3 - Article
C2 - 23300084
AN - SCOPUS:84874287635
SN - 0021-9258
VL - 288
SP - 5268
EP - 5277
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 8
ER -