Background: PI(4,5)P2, mainly synthesized by PIP5KI, is essential for normal cell function. Results: Deficiency or overexpression of PIP5KI, which results in decrease or increase of PI(4,5)P2, respectively, impairs osteoclast differentiation and function. Conclusion: Optimal PIP5KI and PI(4,5)P2 expression are important for osteoclast function. Significance: This is the first demonstration that PIP5KI regulates cells in a bifunctional manner.

Original languageEnglish
Pages (from-to)5268-5277
Number of pages10
JournalJournal of Biological Chemistry
Issue number8
StatePublished - Feb 22 2013


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