Type i interferons: Diversity of sources, production pathways and effects on immune responses

Melissa Swiecki, Marco Colonna

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune responses to viruses are also greatly influenced by IFN-I. In this article we discuss the diversity of cellular sources of IFN-I and the pathways leading to IFN-I production during viral infections. Finally, we discuss the effects of IFN-I on cells of the immune system with emphasis on dendritic cells.

Original languageEnglish
Pages (from-to)463-475
Number of pages13
JournalCurrent Opinion in Virology
Volume1
Issue number6
DOIs
StatePublished - Dec 2011

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