TY - JOUR
T1 - Type i interferons
T2 - Diversity of sources, production pathways and effects on immune responses
AU - Swiecki, Melissa
AU - Colonna, Marco
N1 - Funding Information:
These studies were supported by the Juvenile Diabetes Research Foundation (JDRF) grant 24-2007-420 and National Institutes of Health grant CA109673 (to M. Colonna). M. Swiecki was supported by the NRSA training grant 5T32DK007296 from NIDDK. The authors declare no competing financial interests.
PY - 2011/12
Y1 - 2011/12
N2 - Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune responses to viruses are also greatly influenced by IFN-I. In this article we discuss the diversity of cellular sources of IFN-I and the pathways leading to IFN-I production during viral infections. Finally, we discuss the effects of IFN-I on cells of the immune system with emphasis on dendritic cells.
AB - Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune responses to viruses are also greatly influenced by IFN-I. In this article we discuss the diversity of cellular sources of IFN-I and the pathways leading to IFN-I production during viral infections. Finally, we discuss the effects of IFN-I on cells of the immune system with emphasis on dendritic cells.
UR - http://www.scopus.com/inward/record.url?scp=82955233182&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2011.10.026
DO - 10.1016/j.coviro.2011.10.026
M3 - Review article
C2 - 22440910
AN - SCOPUS:82955233182
SN - 1879-6257
VL - 1
SP - 463
EP - 475
JO - Current Opinion in Virology
JF - Current Opinion in Virology
IS - 6
ER -