Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4+ T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4+ T cells to undergo IFN-1-induced Stat4 activation and Th1 development.

Original languageEnglish
Pages (from-to)484-489
Number of pages6
JournalImmunology today
Issue number10
StatePublished - Jan 1 2000


Dive into the research topics of 'Type I interferons and T helper development'. Together they form a unique fingerprint.

Cite this