Type I interferons and T helper development

J. David Farrar; Kenneth M. Murphy

doi:10.1016/S0167-5699(00)01710-2

Type I interferons and T helper development

J. David Farrar, Kenneth M. Murphy

Research output: Contribution to journal › Comment/debate

96 Scopus citations

Abstract

Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4⁺ T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4⁺ T cells to undergo IFN-1-induced Stat4 activation and Th1 development.

Original language	English
Pages (from-to)	484-489
Number of pages	6
Journal	Immunology today
Volume	21
Issue number	10
DOIs	https://doi.org/10.1016/S0167-5699(00)01710-2
State	Published - Jan 1 2000

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title = "Type I interferons and T helper development",

abstract = "Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4+ T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4+ T cells to undergo IFN-1-induced Stat4 activation and Th1 development.",

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AU - Murphy, Kenneth M.

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N2 - Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4+ T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4+ T cells to undergo IFN-1-induced Stat4 activation and Th1 development.

AB - Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4+ T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4+ T cells to undergo IFN-1-induced Stat4 activation and Th1 development.

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U2 - 10.1016/S0167-5699(00)01710-2

DO - 10.1016/S0167-5699(00)01710-2

M3 - Comment/debate

C2 - 11071526

AN - SCOPUS:0033782944

SN - 0167-5699

VL - 21

SP - 484

EP - 489

JO - Immunology today

JF - Immunology today

IS - 10

ER -

Type I interferons and T helper development

Abstract

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