Type 3 renal tubular acidosis associated with growth hormone deficiency

Yin Ping Liew, Timothy A. Rogers, Jane L. Garb, Holley F. Allen, Edward O. Reiter, Thomas J. Campfield, Vikas R. Dharnidharka, Gregory L. Braden

Research output: Contribution to journalArticlepeer-review


We identified two boys with type 3 renal tubular acidosis (RTA) and growth hormone deficiency and we sought to differentiate them from children with classic type 1 distal RTA. We reviewed all children <6 years of age with RTA referred over a 13-year period and compared the growth response to alkali therapy in these two boys and in 28 children with only type 1 distal RTA. All children with type 1 RTA reached the 5th percentile or higher on CDC growth charts within 2 years of alkali therapy. Their mean height standard deviation score (SDS) improved from -1.4 to -0.6 SDS and their mean mid-parental height (MPH) SDS improved from -0.6 to 0 SDS after 2 years. In contrast, the boys with growth hormone deficiency had a height SDS of -1.4 and -2.4 SDS after 2 years of alkali and the MPH SDS were both -2.6 SDS after 2 years of alkali therapy. Growth hormone therapy accelerated their growth to normal levels and led to long-term correction of RTA. A child with type 1 RTA whose height response after 2 years of alkali therapy is inadequate should undergo provocative growth hormone testing.

Original languageEnglish
Pages (from-to)1047-1053
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number10
StatePublished - Oct 26 2017


  • growth hormone deficiency
  • renal tubular acidosis


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