Two-photon microperimetry: Sensitivity of human photoreceptors to infrared light

Daniel Ruminski, Grazyna Palczewska, Maciej Nowakowski, Agnieszka Zielińska, Vladimir J. Kefalov, Katarzyna Komar, Krzysztof Palczewski, Maciej Wojtkowski

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Microperimetry is a subjective ophthalmologic test used to assess retinal function at various specific and focal locations of the visual field. Historically, visible light has been described as ranging from 400 to 720 nm. However, we previously demonstrated that infra-red light can initiate visual transduction in rod photoreceptors by a mechanism of two-photon absorption by visual pigments. Here we introduce a newly designed and constructed two-photon microperimeter. We provide for the first time evidence of the presence of a nonlinear process occurring in the human retina based on psychophysical tests using newly developed instrumentation. Since infra-red light penetrates the aged front of the eye better than visible light, it has the potential for improved functional diagnostics in patients with age-related visual disorders.

Original languageEnglish
Pages (from-to)4551-4567
Number of pages17
JournalBiomedical Optics Express
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2019

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