TY - JOUR
T1 - Two-photon microperimetry
T2 - Sensitivity of human photoreceptors to infrared light
AU - Ruminski, Daniel
AU - Palczewska, Grazyna
AU - Nowakowski, Maciej
AU - Zielińska, Agnieszka
AU - Kefalov, Vladimir J.
AU - Komar, Katarzyna
AU - Palczewski, Krzysztof
AU - Wojtkowski, Maciej
N1 - Publisher Copyright:
© 2019 Optical Society of America.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Microperimetry is a subjective ophthalmologic test used to assess retinal function at various specific and focal locations of the visual field. Historically, visible light has been described as ranging from 400 to 720 nm. However, we previously demonstrated that infra-red light can initiate visual transduction in rod photoreceptors by a mechanism of two-photon absorption by visual pigments. Here we introduce a newly designed and constructed two-photon microperimeter. We provide for the first time evidence of the presence of a nonlinear process occurring in the human retina based on psychophysical tests using newly developed instrumentation. Since infra-red light penetrates the aged front of the eye better than visible light, it has the potential for improved functional diagnostics in patients with age-related visual disorders.
AB - Microperimetry is a subjective ophthalmologic test used to assess retinal function at various specific and focal locations of the visual field. Historically, visible light has been described as ranging from 400 to 720 nm. However, we previously demonstrated that infra-red light can initiate visual transduction in rod photoreceptors by a mechanism of two-photon absorption by visual pigments. Here we introduce a newly designed and constructed two-photon microperimeter. We provide for the first time evidence of the presence of a nonlinear process occurring in the human retina based on psychophysical tests using newly developed instrumentation. Since infra-red light penetrates the aged front of the eye better than visible light, it has the potential for improved functional diagnostics in patients with age-related visual disorders.
UR - http://www.scopus.com/inward/record.url?scp=85078707687&partnerID=8YFLogxK
U2 - 10.1364/BOE.10.004551
DO - 10.1364/BOE.10.004551
M3 - Article
C2 - 31565509
AN - SCOPUS:85078707687
SN - 2156-7085
VL - 10
SP - 4551
EP - 4567
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 9
ER -