Two close, too close: Sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate

Gerald W. Dorn, Luca Scorrano

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations

Abstract

Mitochondria are key organelles in cell life whose dysfunction is associated with a variety of diseases. Their crucial role in intermediary metabolism and energy conversion makes them a preferred target in tissues, such as the heart, where the energetic demands are very high. In the cardiomyocyte, the spatial organization of mitochondria favors their interaction with the sarcoplasmic reticulum, thereby offering a mechanism for Ca-mediated crosstalk between these 2 organelles. Recently, the molecular basis for this interaction has begun to be unraveled, and we are learning how endoplasmic reticulum-mitochondrial interactions are often exploited by death signals, such as proapoptotic Bcl-2 family members, to amplify the cell death cascade. Here, we review our present understanding of the structural basis and the functional consequences of the close interaction between sarcoplasmic reticulum and mitochondria on cardiomyocyte function and death.

Original languageEnglish
Pages (from-to)689-699
Number of pages11
JournalCirculation research
Volume107
Issue number6
DOIs
StatePublished - Sep 17 2010

Keywords

  • apoptosis
  • calcium
  • endoplasmic reticulum
  • mitochondrial fusion
  • mitochondrial permeability transition

Fingerprint Dive into the research topics of 'Two close, too close: Sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate'. Together they form a unique fingerprint.

Cite this