Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells

Jesus Calderon; Emil R. Unanue

doi:10.1038/253359a0

Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells

Jesus Calderon
, Emil R. Unanue

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product¹; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells ^1-7.

Original language	English
Pages (from-to)	359-361
Number of pages	3
Journal	Nature
Volume	253
Issue number	5490
DOIs	https://doi.org/10.1038/253359a0
State	Published - 1975

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title = "Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells",

abstract = "WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product1; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells 1-7.",

author = "Jesus Calderon and Unanue, \{Emil R.\}",

year = "1975",

doi = "10.1038/253359a0",

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journal = "Nature",

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AU - Calderon, Jesus

AU - Unanue, Emil R.

PY - 1975

Y1 - 1975

N2 - WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product1; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells 1-7.

AB - WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product1; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells 1-7.

UR - https://www.scopus.com/pages/publications/0016637520

U2 - 10.1038/253359a0

DO - 10.1038/253359a0

M3 - Article

C2 - 1078603

AN - SCOPUS:0016637520

SN - 0028-0836

VL - 253

SP - 359

EP - 361

JO - Nature

JF - Nature

IS - 5490

ER -

Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells

Abstract

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