Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells

Jesus Calderon; Emil R. Unanue

doi:10.1038/253359a0

Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells

Jesus Calderon, Emil R. Unanue

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Abstract

WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product¹; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells ^1-7.

Original language	English
Pages (from-to)	359-361
Number of pages	3
Journal	Nature
Volume	253
Issue number	5490
DOIs	https://doi.org/10.1038/253359a0
State	Published - 1975

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title = "Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells",

abstract = "WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product1; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells 1-7.",

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AU - Unanue, Emil R.

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N2 - WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product1; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells 1-7.

AB - WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product1; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells 1-7.

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Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells

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