Turning a tiger into a house cat: Using Legionella pneumophila to study Coxiella burnetii

Joseph P. Vogel

doi:10.1016/j.tim.2004.01.008

Turning a tiger into a house cat: Using Legionella pneumophila to study Coxiella burnetii

Joseph P. Vogel

Research output: Contribution to journal › Short survey › peer-review

29 Scopus citations

Abstract

Understanding how Coxiella burnetii causes Q fever has proven to be exceedingly difficult owing to its obligate intracellular nature. Sequencing the C. burnetii genome revealed the presence of genes that could encode a type IV secretion system highly homologous to the Dot/Icm system in Legionella pneumophila. Recently, two groups have exploited this similarity by expressing the C. burnetii dot/icm homologues in a surrogate host, L. pneumophila, to determine their function.

Original language	English
Pages (from-to)	103-105
Number of pages	3
Journal	Trends in Microbiology
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.tim.2004.01.008
State	Published - Mar 2004

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10.1016/j.tim.2004.01.008

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abstract = "Understanding how Coxiella burnetii causes Q fever has proven to be exceedingly difficult owing to its obligate intracellular nature. Sequencing the C. burnetii genome revealed the presence of genes that could encode a type IV secretion system highly homologous to the Dot/Icm system in Legionella pneumophila. Recently, two groups have exploited this similarity by expressing the C. burnetii dot/icm homologues in a surrogate host, L. pneumophila, to determine their function.",

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AB - Understanding how Coxiella burnetii causes Q fever has proven to be exceedingly difficult owing to its obligate intracellular nature. Sequencing the C. burnetii genome revealed the presence of genes that could encode a type IV secretion system highly homologous to the Dot/Icm system in Legionella pneumophila. Recently, two groups have exploited this similarity by expressing the C. burnetii dot/icm homologues in a surrogate host, L. pneumophila, to determine their function.

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Turning a tiger into a house cat: Using Legionella pneumophila to study Coxiella burnetii

Abstract

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