Turning a tiger into a house cat: Using Legionella pneumophila to study Coxiella burnetii

Research output: Contribution to journalShort surveypeer-review

26 Scopus citations

Abstract

Understanding how Coxiella burnetii causes Q fever has proven to be exceedingly difficult owing to its obligate intracellular nature. Sequencing the C. burnetii genome revealed the presence of genes that could encode a type IV secretion system highly homologous to the Dot/Icm system in Legionella pneumophila. Recently, two groups have exploited this similarity by expressing the C. burnetii dot/icm homologues in a surrogate host, L. pneumophila, to determine their function.

Original languageEnglish
Pages (from-to)103-105
Number of pages3
JournalTrends in Microbiology
Volume12
Issue number3
DOIs
StatePublished - Mar 1 2004

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