Tumour evolution and microenvironment interactions in 2D and 3D space

Chia Kuei Mo; Jingxian Liu; Siqi Chen; Erik Storrs; Andre Luiz N. Targino da Costa; Andrew Houston; Michael C. Wendl; Reyka G. Jayasinghe; Michael D. Iglesia; Cong Ma; John M. Herndon; Austin N. Southard-Smith; Xinhao Liu; Jacqueline Mudd; Alla Karpova; Andrew Shinkle; S. Peter Goedegebuure; Abdurrahman Taha Mousa Ali Abdelzaher; Peng Bo; Lauren Fulghum; Samantha Livingston; Metin Balaban; Angela Hill; Joseph E. Ippolito; Vesteinn Thorsson; Jason M. Held; Ian S. Hagemann; Eric H. Kim; Peter O. Bayguinov; Albert H. Kim; Mary M. Mullen; Kooresh I. Shoghi; Tao Ju; Melissa A. Reimers; Cody Weimholt; Liang I. Kang; Sidharth V. Puram; Deborah J. Veis; Russell Pachynski; Katherine C. Fuh; Milan G. Chheda; William E. Gillanders; Ryan C. Fields; Benjamin J. Raphael; Feng Chen; Li Ding

doi:10.1038/s41586-024-08087-4

Tumour evolution and microenvironment interactions in 2D and 3D space

Chia Kuei Mo
, Jingxian Liu
, Siqi Chen
, Erik Storrs
, Andre Luiz N. Targino da Costa
, Andrew Houston
, Michael C. Wendl
, Reyka G. Jayasinghe
, Michael D. Iglesia
, Cong Ma
, John M. Herndon
, Austin N. Southard-Smith
, Xinhao Liu
, Jacqueline Mudd
, Alla Karpova
, Andrew Shinkle
, S. Peter Goedegebuure
, Abdurrahman Taha Mousa Ali Abdelzaher
, Peng Bo
, Lauren Fulghum

Samantha Livingston, Metin Balaban, Angela Hill, Joseph E. Ippolito, Vesteinn Thorsson, Jason M. Held, Ian S. Hagemann, Eric H. Kim, Peter O. Bayguinov, Albert H. Kim, Mary M. Mullen, Kooresh I. Shoghi, Tao Ju, Melissa A. Reimers, Cody Weimholt, Liang I. Kang, Sidharth V. Puram, Deborah J. Veis, Russell Pachynski, Katherine C. Fuh, Milan G. Chheda, William E. Gillanders, Ryan C. Fields, Benjamin J. Raphael, Feng Chen, Li Ding

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Visium spatial transcriptomics, single-nucleus RNA sequencing and co-detection by indexing are used to identify distinct spatial microregions in tumours and their microenvironment across six diverse solid cancer types.

Original language	English
Pages (from-to)	1178-1186
Number of pages	9
Journal	Nature
Volume	634
Issue number	8036
DOIs	https://doi.org/10.1038/s41586-024-08087-4
State	Published - Oct 31 2024

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Mo, C. K., Liu, J., Chen, S., Storrs, E., Targino da Costa, A. L. N., Houston, A., Wendl, M. C., Jayasinghe, R. G., Iglesia, M. D., Ma, C., Herndon, J. M., Southard-Smith, A. N., Liu, X., Mudd, J., Karpova, A., Shinkle, A., Goedegebuure, S. P., Abdelzaher, A. T. M. A., Bo, P., ... Ding, L. (2024). Tumour evolution and microenvironment interactions in 2D and 3D space. Nature, 634(8036), 1178-1186. https://doi.org/10.1038/s41586-024-08087-4

@article{e6d89eefd36a4cbbb3c5ac92e7afbb83,

title = "Tumour evolution and microenvironment interactions in 2D and 3D space",

abstract = "Visium spatial transcriptomics, single-nucleus RNA sequencing and co-detection by indexing are used to identify distinct spatial microregions in tumours and their microenvironment across six diverse solid cancer types.",

author = "Mo, \{Chia Kuei\} and Jingxian Liu and Siqi Chen and Erik Storrs and \{Targino da Costa\}, \{Andre Luiz N.\} and Andrew Houston and Wendl, \{Michael C.\} and Jayasinghe, \{Reyka G.\} and Iglesia, \{Michael D.\} and Cong Ma and Herndon, \{John M.\} and Southard-Smith, \{Austin N.\} and Xinhao Liu and Jacqueline Mudd and Alla Karpova and Andrew Shinkle and Goedegebuure, \{S. Peter\} and Abdelzaher, \{Abdurrahman Taha Mousa Ali\} and Peng Bo and Lauren Fulghum and Samantha Livingston and Metin Balaban and Angela Hill and Ippolito, \{Joseph E.\} and Vesteinn Thorsson and Held, \{Jason M.\} and Hagemann, \{Ian S.\} and Kim, \{Eric H.\} and Bayguinov, \{Peter O.\} and Kim, \{Albert H.\} and Mullen, \{Mary M.\} and Shoghi, \{Kooresh I.\} and Tao Ju and Reimers, \{Melissa A.\} and Cody Weimholt and Kang, \{Liang I.\} and Puram, \{Sidharth V.\} and Veis, \{Deborah J.\} and Russell Pachynski and Fuh, \{Katherine C.\} and Chheda, \{Milan G.\} and Gillanders, \{William E.\} and Fields, \{Ryan C.\} and Raphael, \{Benjamin J.\} and Feng Chen and Li Ding",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = oct,

day = "31",

doi = "10.1038/s41586-024-08087-4",

language = "English",

volume = "634",

pages = "1178--1186",

journal = "Nature",

issn = "0028-0836",

number = "8036",

}

Mo, CK, Liu, J, Chen, S, Storrs, E, Targino da Costa, ALN, Houston, A, Wendl, MC , Jayasinghe, RG, Iglesia, MD, Ma, C, Herndon, JM, Southard-Smith, AN, Liu, X, Mudd, J, Karpova, A, Shinkle, A, Goedegebuure, SP, Abdelzaher, ATMA, Bo, P, Fulghum, L, Livingston, S, Balaban, M, Hill, A, Ippolito, JE, Thorsson, V, Held, JM, Hagemann, IS, Kim, EH, Bayguinov, PO , Kim, AH , Mullen, MM , Shoghi, KI , Ju, T , Reimers, MA , Weimholt, C , Kang, LI , Puram, SV , Veis, DJ , Pachynski, R, Fuh, KC, Chheda, MG , Gillanders, WE, Fields, RC, Raphael, BJ, Chen, F & Ding, L 2024, 'Tumour evolution and microenvironment interactions in 2D and 3D space', Nature, vol. 634, no. 8036, pp. 1178-1186. https://doi.org/10.1038/s41586-024-08087-4

TY - JOUR

T1 - Tumour evolution and microenvironment interactions in 2D and 3D space

AU - Mo, Chia Kuei

AU - Liu, Jingxian

AU - Chen, Siqi

AU - Storrs, Erik

AU - Targino da Costa, Andre Luiz N.

AU - Houston, Andrew

AU - Wendl, Michael C.

AU - Jayasinghe, Reyka G.

AU - Iglesia, Michael D.

AU - Ma, Cong

AU - Herndon, John M.

AU - Southard-Smith, Austin N.

AU - Liu, Xinhao

AU - Mudd, Jacqueline

AU - Karpova, Alla

AU - Shinkle, Andrew

AU - Goedegebuure, S. Peter

AU - Abdelzaher, Abdurrahman Taha Mousa Ali

AU - Bo, Peng

AU - Fulghum, Lauren

AU - Livingston, Samantha

AU - Balaban, Metin

AU - Hill, Angela

AU - Ippolito, Joseph E.

AU - Thorsson, Vesteinn

AU - Held, Jason M.

AU - Hagemann, Ian S.

AU - Kim, Eric H.

AU - Bayguinov, Peter O.

AU - Kim, Albert H.

AU - Mullen, Mary M.

AU - Shoghi, Kooresh I.

AU - Ju, Tao

AU - Reimers, Melissa A.

AU - Weimholt, Cody

AU - Kang, Liang I.

AU - Puram, Sidharth V.

AU - Veis, Deborah J.

AU - Pachynski, Russell

AU - Fuh, Katherine C.

AU - Chheda, Milan G.

AU - Gillanders, William E.

AU - Fields, Ryan C.

AU - Raphael, Benjamin J.

AU - Chen, Feng

AU - Ding, Li

PY - 2024/10/31

Y1 - 2024/10/31

N2 - Visium spatial transcriptomics, single-nucleus RNA sequencing and co-detection by indexing are used to identify distinct spatial microregions in tumours and their microenvironment across six diverse solid cancer types.

AB - Visium spatial transcriptomics, single-nucleus RNA sequencing and co-detection by indexing are used to identify distinct spatial microregions in tumours and their microenvironment across six diverse solid cancer types.

UR - https://www.scopus.com/pages/publications/85207970133

U2 - 10.1038/s41586-024-08087-4

DO - 10.1038/s41586-024-08087-4

M3 - Article

C2 - 39478210

AN - SCOPUS:85207970133

SN - 0028-0836

VL - 634

SP - 1178

EP - 1186

JO - Nature

JF - Nature

IS - 8036

ER -

Tumour evolution and microenvironment interactions in 2D and 3D space

Abstract

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