Abstract
Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties ("cancer stem cells"). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 5579-5582 |
| Number of pages | 4 |
| Journal | Cancer research |
| Volume | 67 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jun 15 2007 |