Tumorigenesis in the brain: Location, location, location

Richard J. Gilbertson; David H. Gutmann

doi:10.1158/0008-5472.CAN-07-0760

Tumorigenesis in the brain: Location, location, location

Richard J. Gilbertson, David H. Gutmann

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties ("cancer stem cells"). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors.

Original language	English
Pages (from-to)	5579-5582
Number of pages	4
Journal	Cancer research
Volume	67
Issue number	12
DOIs	https://doi.org/10.1158/0008-5472.CAN-07-0760
State	Published - Jun 15 2007

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10.1158/0008-5472.CAN-07-0760

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N2 - Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties ("cancer stem cells"). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors.

AB - Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties ("cancer stem cells"). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors.

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DO - 10.1158/0008-5472.CAN-07-0760

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Tumorigenesis in the brain: Location, location, location

Abstract

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