Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor

S. S. Houshmandi; E. I. Surace; H. B. Zhang; G. N. Fuller; D. H. Gutmann

doi:10.1212/01.wnl.0000244472.56198.84

Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor

S. S. Houshmandi, E. I. Surace, H. B. Zhang, G. N. Fuller, D. H. Gutmann

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19 Scopus citations

Abstract

Tumor suppressor in lung cancer-1 (TSLC1) loss is common in many human cancers, including meningioma. In this study, we demonstrate that TSLC1 protein and RNA expression is lost in 60% to 65% of high-grade gliomas, and that TSLC1 reintroduction into glioma cells results in growth suppression. Moreover, Tslc1 loss in mice results in increased astrocyte proliferation in vivo and in vitro. These data indicate that TSLC1 functions as a glioma tumor suppressor.

Original language	English
Pages (from-to)	1863-1866
Number of pages	4
Journal	Neurology
Volume	67
Issue number	10
DOIs	https://doi.org/10.1212/01.wnl.0000244472.56198.84
State	Published - Nov 2006

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abstract = "Tumor suppressor in lung cancer-1 (TSLC1) loss is common in many human cancers, including meningioma. In this study, we demonstrate that TSLC1 protein and RNA expression is lost in 60% to 65% of high-grade gliomas, and that TSLC1 reintroduction into glioma cells results in growth suppression. Moreover, Tslc1 loss in mice results in increased astrocyte proliferation in vivo and in vitro. These data indicate that TSLC1 functions as a glioma tumor suppressor.",

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AU - Surace, E. I.

AU - Zhang, H. B.

AU - Fuller, G. N.

AU - Gutmann, D. H.

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AB - Tumor suppressor in lung cancer-1 (TSLC1) loss is common in many human cancers, including meningioma. In this study, we demonstrate that TSLC1 protein and RNA expression is lost in 60% to 65% of high-grade gliomas, and that TSLC1 reintroduction into glioma cells results in growth suppression. Moreover, Tslc1 loss in mice results in increased astrocyte proliferation in vivo and in vitro. These data indicate that TSLC1 functions as a glioma tumor suppressor.

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Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor

Abstract

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