Tumor-suppressive maspin functions as a reactive oxygen species scavenger: Importance of cysteine residues

Background: Maspin is a multifaceted serpin, but the role of intracellular maspin is still not well understood. Results: Our study provides evidence that the structurally exposed cysteine residues in maspin reduce oxidative stress and cell proliferation. Conclusion: Cysteine thiols in maspin scavenge reactive oxygen species in tumor cells. Significance: These findings elucidate the importance of cysteine residues of maspin in curbing oxidative stress.