Tumor-specific regulatory T cells in cancer patients

Sytse J. Piersma, Marij J.P. Welters, Sjoerd H. van der Burg

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

A large body of evidence indicates that the presence of regulatory T cells (Tregs) in tumors is associated with a dampened tumor-specific immune response and a clear negative impact on survival. Many different subsets of Tregs have been identified, which all act through similar or distinct pathways to suppress tumor-specific effector cells. The observation that tumor-infiltrating Tregs are able to recognize tumor-derived antigens and can be expanded by vaccines that primarily aim at reinforcing the effector arm of the antitumor response stresses the need to study Tregs for each type of cancer targeted by immunotherapy. Current protocols enable us to isolate and culture tumor-infiltrating Tregs. Ultimately, this will not only lead to a full comprehension of the specificity and working mechanisms of Tregs but also facilitate the development of successful interventions strategies for the immunotherapy of cancer.

Original languageEnglish
Pages (from-to)241-249
Number of pages9
JournalHuman Immunology
Volume69
Issue number4-5
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Keywords

  • Culture
  • Generation
  • Immune suppression
  • Regulatory T cell
  • Tumor

Fingerprint Dive into the research topics of 'Tumor-specific regulatory T cells in cancer patients'. Together they form a unique fingerprint.

  • Cite this