TY - JOUR
T1 - Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice
AU - Flynn, Jo Anne L.
AU - Goldstein, Marsha M.
AU - Chan, John
AU - Triebold, Karla J.
AU - Pfeffer, Klaus
AU - Lowenstein, Charles J.
AU - Schrelber, Robert
AU - Mak, Tak W.
AU - Bloom, Barry R.
PY - 1995/6
Y1 - 1995/6
N2 - Understanding the immunological mechanisms of protection and pathogenesis in tuberculosis remains problematic. We have examined the extent to which tumor necrosis factor-α (TNFα) contributes to this disease using murine models In which the action of TNFα is inhibited. TNFa was neutralized In vivo by monoclonal antibody; in addition, a mouse strain with a disruption in the gene for the 55 kDa TNF receptor was used. The data from both models established that TNFα and the 55 kDa TNF receptor are essential for protection against tuberculosis in mice, and for reactive nitrogen production by macrophages early in infection. Granulomas were formed in equal numbers in control and experimental mice, but necrosis was observed only in mice deficient in TNFα or TNF receptor. TNFα and the 55 kDa TNF receptor are necessary conditions for protection against murine M. tuberculosis infection, but are not solely responsible for the tissue damage observed.
AB - Understanding the immunological mechanisms of protection and pathogenesis in tuberculosis remains problematic. We have examined the extent to which tumor necrosis factor-α (TNFα) contributes to this disease using murine models In which the action of TNFα is inhibited. TNFa was neutralized In vivo by monoclonal antibody; in addition, a mouse strain with a disruption in the gene for the 55 kDa TNF receptor was used. The data from both models established that TNFα and the 55 kDa TNF receptor are essential for protection against tuberculosis in mice, and for reactive nitrogen production by macrophages early in infection. Granulomas were formed in equal numbers in control and experimental mice, but necrosis was observed only in mice deficient in TNFα or TNF receptor. TNFα and the 55 kDa TNF receptor are necessary conditions for protection against murine M. tuberculosis infection, but are not solely responsible for the tissue damage observed.
UR - http://www.scopus.com/inward/record.url?scp=0028979703&partnerID=8YFLogxK
U2 - 10.1016/1074-7613(95)90001-2
DO - 10.1016/1074-7613(95)90001-2
M3 - Article
C2 - 7540941
AN - SCOPUS:0028979703
SN - 1074-7613
VL - 2
SP - 561
EP - 572
JO - Immunity
JF - Immunity
IS - 6
ER -