Tumor necrosis factor‐α and the failing human heart–TNFα and heart failure

Hakan Oral, Samir Kapadia, Masayuki Nakano, Guillermo Torre‐Amione, Joseph Lee, Dorellyn Lee‐Jackson, James B. Young, Douglas L. Mann

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Tumor necrosis factor‐alpha (TNFα) is a proin‐flammatory cytokine with negative inotropic effects. Recently, elevated levels of TNFα have been identified in patients with advanced heart failure. Although the clinical significance of this finding is unclear at present, there is increasing evidence that this cytokine may play a primary pathophysiologic role in the development and pathogenesis of heart failure in humans. Indeed, many of the clinical hallmarks of heart failure, including left ventricular dysfunction, cardiomyopathy, and pulmonary edema can be explained by the known biological effects of TNFα in humans. The present review will summarize recent evidence with regard to the biological role for TNFα in the adult mammalian heart, as well as summarize the increasing body of clinical information that implicates this cytokine in the pathophysiology of heart failure.

Original languageEnglish
Pages (from-to)IV20-IV27
JournalClinical Cardiology
Issue number4 S
StatePublished - Sep 1995


  • congestive heart failure
  • cytokines
  • tumor necrosis factor alpha (TNFα)


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