Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance

Rongbin Ge, Zongwei Wang, Liang Cheng

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Prostate cancer is characterized by a high degree of heterogeneity, which poses a major challenge to precision therapy and drug development. In this review, we discuss how nongenetic factors contribute to heterogeneity of prostate cancer. We also discuss tumor heterogeneity and phenotypic switching related to anticancer therapies. Lastly, we summarize the challenges targeting the tumor environments, and emphasize that continued exploration of tumor heterogeneity is needed in order to offer a personalized therapy for advanced prostate cancer patients.

Original languageEnglish
Article number31
Journalnpj Precision Oncology
Volume6
Issue number1
DOIs
StatePublished - Dec 2022

Fingerprint

Dive into the research topics of 'Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance'. Together they form a unique fingerprint.

Cite this