@article{8e5578f31ba44e20ab232ff270d63e8c,
title = "Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression",
abstract = "Tumor cells evade immune responses by producing high levels of retinoic acid, which directs intratumoral monocytes to differentiate into immunosuppressive macrophages rather than immunostimulatory dendritic cells.",
keywords = "dendritic cell, immune checkpoint blockade, immune evasion, macrophage, monocyte, retinoic acid, tumor microenvironment",
author = "Samir Devalaraja and To, {Tsun Ki Jerrick} and Folkert, {Ian W.} and Ramakrishnan Natesan and Alam, {Md Zahidul} and Minghong Li and Yuma Tada and Konstantin Budagyan and Dang, {Mai T.} and Li Zhai and Lobel, {Graham P.} and Ciotti, {Gabrielle E.} and Eisinger-Mathason, {T. S.Karin} and Asangani, {Irfan A.} and Kristy Weber and Simon, {M. Celeste} and Malay Haldar",
note = "Funding Information: We thank Drs. Brian Keith and Ivan Maillard for their scientific input and Dr. Michael Gonzalez for help with scRNA-seq. We thank Y. Daikhin, O. Horyn, and Ilanna Nissim for performing the ATRA measurements in the Metabolomics Core Facility, The Children{\textquoteright}s Hospital of Philadelphia (CHOP). We also thank FCM cores at UPenn and CHOP, CAG Core at CHOP, and HIC core at UPenn. This work was supported by the NCI-R37 CA234027 (M.H.), Burroughs Wellcome CAMS (M.H.), the Concern Foundation (M.H.), the Slay Sarcoma Research Initiative (M.H.), the Sarcoma Program at UPenn (M.H.), and NIH F30CA236464 (S.D.). Funding Information: We thank Drs. Brian Keith and Ivan Maillard for their scientific input and Dr. Michael Gonzalez for help with scRNA-seq. We thank Y. Daikhin, O. Horyn, and Ilanna Nissim for performing the ATRA measurements in the Metabolomics Core Facility, The Children's Hospital of Philadelphia (CHOP). We also thank FCM cores at UPenn and CHOP, CAG Core at CHOP, and HIC core at UPenn. This work was supported by the NCI-R37 CA234027 (M.H.), Burroughs Wellcome CAMS (M.H.), the Concern Foundation (M.H.), the Slay Sarcoma Research Initiative (M.H.), the Sarcoma Program at UPenn (M.H.), and NIH F30CA236464 (S.D.). Conception and Design, S.D. and M.H.; Development of Methodology, S.D. R.N. I.A.A. and M.H.; Data Acquisition: S.D. T.K.J.T. I.W.F. M.Z.A. M.L. Y.T. K.B. M.T.D. G.P.L. G.E.C. R.N. and M.H.; Analysis and Data Interpretation, S.D. T.K.J.T. I.W.F. R.N. I.A.A. T.S.K.E.-M. K.W. and M.H.; Writing, Review, and/or Revision of the Manuscript, S.D. M.C.S. and M.H.; Study Supervision: S.D. and M.H. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = mar,
day = "19",
doi = "10.1016/j.cell.2020.02.042",
language = "English",
volume = "180",
pages = "1098--1114.e16",
journal = "Cell",
issn = "0092-8674",
number = "6",
}