Tumor control in long-term survivors following superficial hyperthermia

Robert J. Myerson, Carlos A. Perez, Bahman Emami, William Straube, Robert R. Kuske, Leonid Leybovich, Debra Von Gerichten

Research output: Contribution to journalArticle

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Abstract

Sixty tumors with a minimum of 1-year follow-up were treated with radiation and superficial microwave hyperthermia (915 MHz). The overall local control rate was 50% ( 30 60). The most important factor in outcome was appropriateness of the hyperthermia applicator. Tumors covered by at least the 25% iso-SAR contour achieved 65% local control versus 21% local control with less than 25% SAR coverage (p < 0.01). Several measures of adequate minimum monitored tumor temperature and duration were considered. The measure best correlated with outcome was best single session time at or above 43°C (t43). If each monitored tumor catheter achieved t43 ≥ 30 minutes in at least one session, then tumor control was significantly (p < 0.01) improved (63% with Min t43 ≥ 30 versus 25% with Min t43 < 30). Although there was considerable overlap between tumors with SAR ≥ 25% and those achieving Min t43 ≥ 30, a statistically significant (p = 0.02) difference could be demonstrated between the group meeting both the SAR and the minimum tumor time/duration standards as opposed to those meeting only one standard. The actuarial local progression-free survival for tumors most likely to have had adequate hyperthermia (defined as SAR ≥ 25% and Min t43 > 30) and all other tumors did not begin to separate significantly until 8 to 12 months after treatment. Implications for future randomized studies are discussed.

Original languageEnglish
Pages (from-to)1123-1129
Number of pages7
JournalInternational journal of radiation oncology, biology, physics
Volume18
Issue number5
DOIs
StatePublished - May 1990

Keywords

  • Hyperthermia physics
  • Microwave hyperthermia
  • Superficial hyperthermia

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