Tubulointerstitial Diseases

J. P. Gaut, H. Liapis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


A wide variety of pathologic processes may affect the renal tubulointerstitium. The cLinical term acute kidney injury refers to a rapid increase in serum creatinine concentration. Under the majority of circumstances, such a rapid rise in serum creatinine is related to acute tubular damage. However, the etiologies of acute tubular damage are varied and may overlap, particularly in the critical care setting. This chapter discusses various causes of tubulointerstitial disease and their underlying pathophysiologic mechanisms.

Original languageEnglish
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Number of pages4
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
StatePublished - Jan 1 2014


  • Acute interstitial nephritis
  • Acute kidney injury
  • Acute pyelonephritis
  • Chronic pyelonephritis
  • Oxalate nephropathy
  • Sepsis
  • Uric acid nephropathy


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