Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

Ilaria Testi; Rupesh Agrawal; Sarakshi Mahajan; Aniruddha Agarwal; Dinesh Visva Gunasekeran; Dhananjay Raje; Kanika Aggarwal; Somasheila I. Murthy; Mark Westcott; Soon Phaik Chee; Peter McCluskey; Su Ling Ho; Stephen Teoh; Luca Cimino; Jyotirmay Biswas; Shishir Narain; Manisha Agarwal; Padmamalini Mahendradas; Moncef Khairallah; Nicholas Jones; Ilknur Tugal-Tutkun; Kalpana Babu; Soumayava Basu; Ester Carreño; Richard Lee; Hassan Al-Dhibi; Bahram Bodaghi; Alessandro Invernizzi; Debra A. Goldstein; Carl P. Herbort; Talin Barisani-Asenbauer; Julio J. González-López; Sofia Androudi; Reema Bansal; Bruttendu Moharana; Simona Degli Esposti; Anastasia Tasiopoulou; Sengal Nadarajah; Mamta Agarwal; Sharanya Abraham; Ruchi Vala; Ramandeep Singh; Aman Sharma; Kusum Sharma; Manfred Zierhut; Andres Rousselot; Robert Grant; Onn Min Kon; Emmett T. Cunningham; John Kempen; Quan Dong Nguyen; Carlos Pavesio; Vishali Gupta

doi:10.1080/09273948.2019.1646774

Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

Ilaria Testi, Rupesh Agrawal, Sarakshi Mahajan, Aniruddha Agarwal, Dinesh Visva Gunasekeran, Dhananjay Raje, Kanika Aggarwal, Somasheila I. Murthy, Mark Westcott, Soon Phaik Chee, Peter McCluskey, Su Ling Ho, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas JonesIlknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Ester Carreño, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Simona Degli Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Andres Rousselot, Robert Grant, Onn Min Kon, Emmett T. Cunningham, John Kempen, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta

Division of Hospital Medicine

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Background: Tuberculosis (TB) is a major infection that can affect the eye as first and sole presentation without features of systemic disease. Controversy exists regarding diagnosis and management of tubercular uveitis (TBU), further compounded by regional variations in disease expression. Purpose: Collaborative Ocular Tuberculosis Study (COTS)-1 aims to address knowledge deficits through collaboration amongst uveitis specialists across the globe by sharing the data of patients with TBU presented at participating centers from January 2004 to December 2014. Methods: Data collection was facilitated by a novel method of real-time encrypted web-based data entry allowing regular updates as new data and recommendations become available. Results: Information on clinical features, investigation findings, management, and treatment outcomes were reviewed to get an idea about real world scenario. Conclusion: The current review aims to focus on methodology and briefing of published reports from COTS group in COTS-1 study to highlight key messages from this large data.

Original language	English
Pages (from-to)	8-16
Number of pages	9
Journal	Ocular Immunology and Inflammation
Volume	28
Issue number	sup1
DOIs	https://doi.org/10.1080/09273948.2019.1646774
State	Published - 2020

Keywords

Anti-tubercular therapy
Collaborative Ocular Tuberculosis Study (COTS)
choroiditis
global experts
tubercular uveitis
tuberculosis

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10.1080/09273948.2019.1646774

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Testi, I., Agrawal, R., Mahajan, S., Agarwal, A., Gunasekeran, D. V., Raje, D., Aggarwal, K., Murthy, S. I., Westcott, M., Chee, S. P., McCluskey, P., Ho, S. L., Teoh, S., Cimino, L., Biswas, J., Narain, S., Agarwal, M., Mahendradas, P., Khairallah, M., ... Gupta, V. (2020). Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1. Ocular Immunology and Inflammation, 28(sup1), 8-16. https://doi.org/10.1080/09273948.2019.1646774

@article{2320f75b0b334935b538e90c805d0655,

title = "Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1",

abstract = "Background: Tuberculosis (TB) is a major infection that can affect the eye as first and sole presentation without features of systemic disease. Controversy exists regarding diagnosis and management of tubercular uveitis (TBU), further compounded by regional variations in disease expression. Purpose: Collaborative Ocular Tuberculosis Study (COTS)-1 aims to address knowledge deficits through collaboration amongst uveitis specialists across the globe by sharing the data of patients with TBU presented at participating centers from January 2004 to December 2014. Methods: Data collection was facilitated by a novel method of real-time encrypted web-based data entry allowing regular updates as new data and recommendations become available. Results: Information on clinical features, investigation findings, management, and treatment outcomes were reviewed to get an idea about real world scenario. Conclusion: The current review aims to focus on methodology and briefing of published reports from COTS group in COTS-1 study to highlight key messages from this large data.",

keywords = "Anti-tubercular therapy, Collaborative Ocular Tuberculosis Study (COTS), choroiditis, global experts, tubercular uveitis, tuberculosis",

author = "Ilaria Testi and Rupesh Agrawal and Sarakshi Mahajan and Aniruddha Agarwal and Gunasekeran, {Dinesh Visva} and Dhananjay Raje and Kanika Aggarwal and Murthy, {Somasheila I.} and Mark Westcott and Chee, {Soon Phaik} and Peter McCluskey and Ho, {Su Ling} and Stephen Teoh and Luca Cimino and Jyotirmay Biswas and Shishir Narain and Manisha Agarwal and Padmamalini Mahendradas and Moncef Khairallah and Nicholas Jones and Ilknur Tugal-Tutkun and Kalpana Babu and Soumayava Basu and Ester Carre{\~n}o and Richard Lee and Hassan Al-Dhibi and Bahram Bodaghi and Alessandro Invernizzi and Goldstein, {Debra A.} and Herbort, {Carl P.} and Talin Barisani-Asenbauer and Gonz{\'a}lez-L{\'o}pez, {Julio J.} and Sofia Androudi and Reema Bansal and Bruttendu Moharana and Esposti, {Simona Degli} and Anastasia Tasiopoulou and Sengal Nadarajah and Mamta Agarwal and Sharanya Abraham and Ruchi Vala and Ramandeep Singh and Aman Sharma and Kusum Sharma and Manfred Zierhut and Andres Rousselot and Robert Grant and Kon, {Onn Min} and Cunningham, {Emmett T.} and John Kempen and Nguyen, {Quan Dong} and Carlos Pavesio and Vishali Gupta",

note = "Publisher Copyright: {\textcopyright} 2019 Taylor & Francis Group, LLC.",

year = "2020",

doi = "10.1080/09273948.2019.1646774",

language = "English",

volume = "28",

pages = "8--16",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

number = "sup1",

}

Testi, I, Agrawal, R, Mahajan, S, Agarwal, A, Gunasekeran, DV, Raje, D, Aggarwal, K, Murthy, SI, Westcott, M, Chee, SP, McCluskey, P, Ho, SL, Teoh, S, Cimino, L, Biswas, J, Narain, S, Agarwal, M, Mahendradas, P, Khairallah, M, Jones, N, Tugal-Tutkun, I, Babu, K, Basu, S, Carreño, E, Lee, R, Al-Dhibi, H, Bodaghi, B, Invernizzi, A, Goldstein, DA, Herbort, CP, Barisani-Asenbauer, T, González-López, JJ, Androudi, S, Bansal, R, Moharana, B, Esposti, SD, Tasiopoulou, A, Nadarajah, S, Agarwal, M, Abraham, S, Vala, R, Singh, R, Sharma, A, Sharma, K, Zierhut, M, Rousselot, A, Grant, R, Kon, OM, Cunningham, ET, Kempen, J, Nguyen, QD, Pavesio, C & Gupta, V 2020, 'Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1', Ocular Immunology and Inflammation, vol. 28, no. sup1, pp. 8-16. https://doi.org/10.1080/09273948.2019.1646774

TY - JOUR

T1 - Tubercular Uveitis

T2 - Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

AU - Testi, Ilaria

AU - Agrawal, Rupesh

AU - Mahajan, Sarakshi

AU - Agarwal, Aniruddha

AU - Gunasekeran, Dinesh Visva

AU - Raje, Dhananjay

AU - Aggarwal, Kanika

AU - Murthy, Somasheila I.

AU - Westcott, Mark

AU - Chee, Soon Phaik

AU - McCluskey, Peter

AU - Ho, Su Ling

AU - Teoh, Stephen

AU - Cimino, Luca

AU - Biswas, Jyotirmay

AU - Narain, Shishir

AU - Agarwal, Manisha

AU - Mahendradas, Padmamalini

AU - Khairallah, Moncef

AU - Jones, Nicholas

AU - Tugal-Tutkun, Ilknur

AU - Babu, Kalpana

AU - Basu, Soumayava

AU - Carreño, Ester

AU - Lee, Richard

AU - Al-Dhibi, Hassan

AU - Bodaghi, Bahram

AU - Invernizzi, Alessandro

AU - Goldstein, Debra A.

AU - Herbort, Carl P.

AU - Barisani-Asenbauer, Talin

AU - González-López, Julio J.

AU - Androudi, Sofia

AU - Bansal, Reema

AU - Moharana, Bruttendu

AU - Esposti, Simona Degli

AU - Tasiopoulou, Anastasia

AU - Nadarajah, Sengal

AU - Agarwal, Mamta

AU - Abraham, Sharanya

AU - Vala, Ruchi

AU - Singh, Ramandeep

AU - Sharma, Aman

AU - Sharma, Kusum

AU - Zierhut, Manfred

AU - Rousselot, Andres

AU - Grant, Robert

AU - Kon, Onn Min

AU - Cunningham, Emmett T.

AU - Kempen, John

AU - Nguyen, Quan Dong

AU - Pavesio, Carlos

AU - Gupta, Vishali

PY - 2020

Y1 - 2020

N2 - Background: Tuberculosis (TB) is a major infection that can affect the eye as first and sole presentation without features of systemic disease. Controversy exists regarding diagnosis and management of tubercular uveitis (TBU), further compounded by regional variations in disease expression. Purpose: Collaborative Ocular Tuberculosis Study (COTS)-1 aims to address knowledge deficits through collaboration amongst uveitis specialists across the globe by sharing the data of patients with TBU presented at participating centers from January 2004 to December 2014. Methods: Data collection was facilitated by a novel method of real-time encrypted web-based data entry allowing regular updates as new data and recommendations become available. Results: Information on clinical features, investigation findings, management, and treatment outcomes were reviewed to get an idea about real world scenario. Conclusion: The current review aims to focus on methodology and briefing of published reports from COTS group in COTS-1 study to highlight key messages from this large data.

AB - Background: Tuberculosis (TB) is a major infection that can affect the eye as first and sole presentation without features of systemic disease. Controversy exists regarding diagnosis and management of tubercular uveitis (TBU), further compounded by regional variations in disease expression. Purpose: Collaborative Ocular Tuberculosis Study (COTS)-1 aims to address knowledge deficits through collaboration amongst uveitis specialists across the globe by sharing the data of patients with TBU presented at participating centers from January 2004 to December 2014. Methods: Data collection was facilitated by a novel method of real-time encrypted web-based data entry allowing regular updates as new data and recommendations become available. Results: Information on clinical features, investigation findings, management, and treatment outcomes were reviewed to get an idea about real world scenario. Conclusion: The current review aims to focus on methodology and briefing of published reports from COTS group in COTS-1 study to highlight key messages from this large data.

KW - Anti-tubercular therapy

KW - Collaborative Ocular Tuberculosis Study (COTS)

KW - choroiditis

KW - global experts

KW - tubercular uveitis

KW - tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=85075498604&partnerID=8YFLogxK

U2 - 10.1080/09273948.2019.1646774

DO - 10.1080/09273948.2019.1646774

M3 - Review article

C2 - 31763952

AN - SCOPUS:85075498604

SN - 0927-3948

VL - 28

SP - 8

EP - 16

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - sup1

ER -

Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

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Keywords

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