TY - JOUR
T1 - T2 preparation method for measuring hyperemic myocardial O 2 consumption
T2 - In vivo validation by positron emission tomography
AU - McCommis, Kyle S.
AU - O'Connor, Robert
AU - Abendschein, Dana R.
AU - Muccigrosso, David
AU - Gropler, Robert J.
AU - Zheng, Jie
PY - 2011/2
Y1 - 2011/2
N2 - Purpose To validate a new T2-prepared method for the quantification of regional myocardial O2 consumption during pharmacologic stress with positron emission tomography (PET). Materials and Methods A T2 prepared gradient-echo sequence was modified to measure myocardial T2 within a single breath-hold. Six beagle dogs were randomly selected for the induction of coronary artery stenosis. Magnetic resonance imaging (MRI) experiments were performed with the T2 imaging and first-pass perfusion imaging at rest and during either dobutamine- or dipyridamole-induced hyperemia. Myocardial blood flow (MBF) was quantified using a previously developed model-free algorithm. Hyperemic myocardial O 2 extraction fraction (OEF) and consumption (MVO2) were calculated using a two-compartment model developed previously. PET imaging using 11C-acetate and 15O-water was performed in the same day to validate OEF, MBF, and MVO2 measurements. Results The T 2-prepared mapping sequence measured regional myocardial T 2 with a repeatability of 2.3%. By myocardial segment-basis analysis, MBF measured by MRI is closely correlated with that measured by PET (R 2 = 0.85, n = 22). Similar correlation coefficients were observed for hyperemic OEF (R2 = 0.90, n = 9, mean difference of PET - MRI = -2.4%) and MVO2 (R2 = 0.83, n = 7, mean difference = 4.2%). Conclusion The T2-prepared imaging method may allow quantitative estimation of regional myocardial oxygenation with relatively good accuracy. The precision of the method remains to be improved.
AB - Purpose To validate a new T2-prepared method for the quantification of regional myocardial O2 consumption during pharmacologic stress with positron emission tomography (PET). Materials and Methods A T2 prepared gradient-echo sequence was modified to measure myocardial T2 within a single breath-hold. Six beagle dogs were randomly selected for the induction of coronary artery stenosis. Magnetic resonance imaging (MRI) experiments were performed with the T2 imaging and first-pass perfusion imaging at rest and during either dobutamine- or dipyridamole-induced hyperemia. Myocardial blood flow (MBF) was quantified using a previously developed model-free algorithm. Hyperemic myocardial O 2 extraction fraction (OEF) and consumption (MVO2) were calculated using a two-compartment model developed previously. PET imaging using 11C-acetate and 15O-water was performed in the same day to validate OEF, MBF, and MVO2 measurements. Results The T 2-prepared mapping sequence measured regional myocardial T 2 with a repeatability of 2.3%. By myocardial segment-basis analysis, MBF measured by MRI is closely correlated with that measured by PET (R 2 = 0.85, n = 22). Similar correlation coefficients were observed for hyperemic OEF (R2 = 0.90, n = 9, mean difference of PET - MRI = -2.4%) and MVO2 (R2 = 0.83, n = 7, mean difference = 4.2%). Conclusion The T2-prepared imaging method may allow quantitative estimation of regional myocardial oxygenation with relatively good accuracy. The precision of the method remains to be improved.
KW - BOLD
KW - T
KW - hyperemia
KW - myocardial oxygen consumption
KW - myocardial perfusion reserve
UR - http://www.scopus.com/inward/record.url?scp=79551511529&partnerID=8YFLogxK
U2 - 10.1002/jmri.22322
DO - 10.1002/jmri.22322
M3 - Article
C2 - 21274973
AN - SCOPUS:79551511529
SN - 1053-1807
VL - 33
SP - 320
EP - 327
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 2
ER -