Tryptophan content for monitoring breast cancer cell aggressiveness by native fluorescence spectroscopy

Lin Zhang, Yang Pu, Jianpeng Xue, Sebastião Pratavieira, Baogang Xu, Samuel Achilefu, R. R. Alfano

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This study shows tryptophan as the key native marker in cells to determine the level of aggressive cancer in breast cell lines using native fluorescence spectroscopy. An algorithm based on the ratio of tryptophan fluorescence intensity at 340 nm to intensity at 460 nm is associated with aggressiveness of the cancer cells. The higher the ratio is, the more aggressive the tumor towards metastasis.

Original languageEnglish
Title of host publicationOptical Biopsy XII
PublisherSPIE
ISBN (Print)9780819498533
DOIs
StatePublished - Jan 1 2014
EventOptical Biopsy XII - San Francisco, CA, United States
Duration: Feb 4 2014Feb 5 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8940
ISSN (Print)1605-7422

Conference

ConferenceOptical Biopsy XII
CountryUnited States
CitySan Francisco, CA
Period02/4/1402/5/14

Keywords

  • Aggressive cancer
  • Cancer markers
  • Fluorescence spectroscopy
  • Metastasis
  • NADH
  • Native fluoresce (NFL)
  • Tryptophan

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