@article{b7b917f0f28c4992ac7c741adbfd89d6,
title = "Tryptophan as the fingerprint for distinguishing aggressiveness among breast cancer cell lines using native fluorescence spectroscopy",
abstract = "Tryptophan is investigated as the key native marker in cells to determine the level of metastasis competence in breast cell lines using native fluorescence spectroscopy. The ratio of fluorescence intensity at 340 nm to intensity at 460 nm is associated with aggressiveness of the cancer cells. We found that the fluorescence of aggressive breast cancer cell has a much higher contribution from tryptophan compared with that from the normal cells and nonaggressive breast cancer cell.",
keywords = "aggressive breast cancer cells, cancer markers, metastasis, native fluorescence spectroscopy, tryptophan",
author = "Lin Zhang and Yang Pu and Jianpeng Xue and Sebasti{\~a}o Pratavieira and Baogang Xu and Samuel Achilefu and Alfano, {Robert R.}",
note = "Funding Information: This research is supported in part by U. S. Army Medical Research and Material Command grants numbered W81XWH-11-1-0335 and W81XWH-08-1-0717. Authors acknowledge Ms. Laura Sordillo in Department of Physics at the City College of the City University of New York for taking part in measuring NFL of MB-MDA-231. R.R.A. thanks Professor Bingmei Fu for use of her cell laboratory facility.",
year = "2014",
month = mar,
doi = "10.1117/1.JBO.19.3.037005",
language = "English",
volume = "19",
journal = "Journal of biomedical optics",
issn = "1083-3668",
number = "3",
}