Trophoblast biology, responses to hypoxia and placental dysfunction in preeclampsia

Roxane Rampersad, D. Michael Nelson

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Preeclampsia is a hypertensive disorder unique to human pregnancy that can result in significant morbidity and mortality for mother and fetus. While the etiology of preeclampsia is unknown, the placenta in general and trophoblast in particular is a prerequisite for the disease. We overview normal development of the human placenta, describe the role of hypoxia and other insults in placental injury, and highlight how the dysregulation of villous trophoblast biology in the second half of pregnancy may incite the pathophysiology of preeclampsia in the mother.

Original languageEnglish
Pages (from-to)2447-2456
Number of pages10
JournalFrontiers in Bioscience
Volume12
Issue number7
DOIs
StatePublished - Jan 1 2007

Keywords

  • Hypoxia
  • Placenta
  • Preeclampsia
  • Review
  • Trophoblast

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