Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation

Feng Qiao Li, Xiu Zhi Lu, Xi Bin Liang, Hui Fang Zhou, Bing Xue, Xian Yu Liu, Dong Bin Niu, Ji Sheng Han, Xiao Min Wang

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Mounting lines of evidence have suggested that brain inflammation participates in the pathogenesis of Parkinson's disease. Triptolide is one of the major active components of Chinese herb Tripterygium wilfordii Hook F, which possesses potent anti-inflammatory and immunosuppressive properties. We found that triptolide concentration-dependently attenuated the lipopolysaccharide (LPS)-induced decrease in [3H]dopamine uptake and loss of tyrosine hydroxylase-immunoreactive neurons in primary mesencephalic neuron/glia mixed culture. Triptolide also blocked LPS-induced activation of microglia and excessive production of TNFα and NO. Our data suggests that triptolide may protect dopaminergic neurons from LPS-induced injury and its efficiency in inhibiting microglia activation may underlie the mechanism.

Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalJournal of Neuroimmunology
Volume148
Issue number1-2
DOIs
StatePublished - Mar 2004

Keywords

  • Inflammation
  • Microglia
  • Neurodegeneration
  • Parkinson's disease
  • Tripterygium wilfordii Hook F
  • Triptolide

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