TY - JOUR
T1 - Triple-head SPECT with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG)
T2 - Initial evaluation in oncology and comparison with FDG PET
AU - Macfarlane, David J.
AU - Cotton, Lisa
AU - Ackermann, Robert J.
AU - Minn, Heikki
AU - Ficaro, Edward P.
AU - Shreve, Paul D.
AU - Wahl, Richard L.
PY - 1995/2
Y1 - 1995/2
N2 - PURPOSE: In patients with cancer, performance was assessed of a commercially available triple-head gamma camera fired with ultra-high energy parallel-hole collimators performing single photon emission computed tomography (SPECT) with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG). Results were compared with those of positron emission tomography (PET) with FDG. MATERIALS AND METHODS: Performance characteristics were first determined in phantom studies for FDG PET and triple-head gamma camera SPECT systems. In 13 patients with malignancies, FDG PET was followed by SPECT of the same region, and imaging results were independently assessed. RESULTS: Sensitivity of the PET and SPECT systems was 58.3 counts/MBq/ rain and 4.5 counts/MBq/min, respectively. Reconstructed spatial resolution was approximately 7 mm for PET and 20 mm for SPECT. All known cancer foci were detected at PET. SPECT depicted 11 of the 22 lesions detected at PET, but only five of the 14 lesions less than 3 cm in diameter. CONCLUSION: FDG SPECT performed with a specially collimated triple-head gamma camera depicted some cancers but had an unacceptably low sensitivity compared with PET for lesions less than 3 cm in diameter. PET is preferable for detecting small cancers.
AB - PURPOSE: In patients with cancer, performance was assessed of a commercially available triple-head gamma camera fired with ultra-high energy parallel-hole collimators performing single photon emission computed tomography (SPECT) with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG). Results were compared with those of positron emission tomography (PET) with FDG. MATERIALS AND METHODS: Performance characteristics were first determined in phantom studies for FDG PET and triple-head gamma camera SPECT systems. In 13 patients with malignancies, FDG PET was followed by SPECT of the same region, and imaging results were independently assessed. RESULTS: Sensitivity of the PET and SPECT systems was 58.3 counts/MBq/ rain and 4.5 counts/MBq/min, respectively. Reconstructed spatial resolution was approximately 7 mm for PET and 20 mm for SPECT. All known cancer foci were detected at PET. SPECT depicted 11 of the 22 lesions detected at PET, but only five of the 14 lesions less than 3 cm in diameter. CONCLUSION: FDG SPECT performed with a specially collimated triple-head gamma camera depicted some cancers but had an unacceptably low sensitivity compared with PET for lesions less than 3 cm in diameter. PET is preferable for detecting small cancers.
KW - Emission CT (ECT)
KW - Emission CT (ECT), technology
UR - http://www.scopus.com/inward/record.url?scp=0028836235&partnerID=8YFLogxK
U2 - 10.1148/radiology.194.2.7824722
DO - 10.1148/radiology.194.2.7824722
M3 - Article
C2 - 7824722
AN - SCOPUS:0028836235
VL - 194
SP - 425
EP - 429
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 2
ER -