TY - JOUR
T1 - Triglyceride, cholesterol and weight changes among risperidone-treated youths
T2 - A retrospective study
AU - Martin, A.
AU - L'Ecuyer, S.
PY - 2002
Y1 - 2002
N2 - The purpose of this retrospective chart review was to assess triglyceride, cholesterol and weight changes among risperidone-treated youths. The charts of 22 child and adolescent inpatients were abstracted. The sample's mean (±SD) age was 12.8 (±2.6) years, daily risperidone dose 2.7 (±2.2) mg, and average length of exposure 4.9 (±1.0) months. Repeated measures analysis of variance revealed statistically and clinically significant weight gain averaging 7.0 (±4.7) kg (95 % confidence interval [CI] for the mean=4.9, 9.1; F=49.421, df=1,21,p < 0.001). No significant changes in serum triglyceride or cholesterol levels were seen in the group as a whole. Triglyceride levels and weight were strongly correlated with each other: almost 25% of the variance in triglyceride level changes could be explained by weight gain alone (R2=0.22, F=5.526,p=0.029), although such association weakened when excluding subjects (N=5) concurrently treated with lithium or divalproex (R2=0.06, p > 0.05). On the basis of this preliminary report it seems prudent to be clinically vigilant and conservative, recommending regular laboratory monitoring until a clearer picture emerges regarding lipid dysregulation associated with risperidone and other atypical antipsychotic use in children and adolescents.
AB - The purpose of this retrospective chart review was to assess triglyceride, cholesterol and weight changes among risperidone-treated youths. The charts of 22 child and adolescent inpatients were abstracted. The sample's mean (±SD) age was 12.8 (±2.6) years, daily risperidone dose 2.7 (±2.2) mg, and average length of exposure 4.9 (±1.0) months. Repeated measures analysis of variance revealed statistically and clinically significant weight gain averaging 7.0 (±4.7) kg (95 % confidence interval [CI] for the mean=4.9, 9.1; F=49.421, df=1,21,p < 0.001). No significant changes in serum triglyceride or cholesterol levels were seen in the group as a whole. Triglyceride levels and weight were strongly correlated with each other: almost 25% of the variance in triglyceride level changes could be explained by weight gain alone (R2=0.22, F=5.526,p=0.029), although such association weakened when excluding subjects (N=5) concurrently treated with lithium or divalproex (R2=0.06, p > 0.05). On the basis of this preliminary report it seems prudent to be clinically vigilant and conservative, recommending regular laboratory monitoring until a clearer picture emerges regarding lipid dysregulation associated with risperidone and other atypical antipsychotic use in children and adolescents.
KW - Adolescents
KW - Children
KW - Cholesterol
KW - Risperidone
KW - Triglycerides
UR - http://www.scopus.com/inward/record.url?scp=0036380550&partnerID=8YFLogxK
U2 - 10.1007/s00787-002-0255-5
DO - 10.1007/s00787-002-0255-5
M3 - Article
C2 - 12369772
AN - SCOPUS:0036380550
VL - 11
SP - 129
EP - 133
JO - European Child and Adolescent Psychiatry
JF - European Child and Adolescent Psychiatry
SN - 1018-8827
IS - 3
ER -