Triggering receptor expressed on myeloid cells 1 (TREM-1)- Mediated Bcl-2 induction prolongs macrophage survival

Zhihong Yuan; Mansoor Ali Syed; Dipti Panchal; Myungsoo Joo; Marco Colonna; Mark Brantly; Ruxana T. Sadikot

doi:10.1074/jbc.M113.536490

Triggering receptor expressed on myeloid cells 1 (TREM-1)- Mediated Bcl-2 induction prolongs macrophage survival

Zhihong Yuan, Mansoor Ali Syed, Dipti Panchal, Myungsoo Joo, Marco Colonna, Mark Brantly, Ruxana T. Sadikot

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Background: Mechanisms by which triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammation are not fully defined. Results: TREM-1 induces anti-apoptotic protein Bcl-2. Conclusion: Macrophage survival is prolonged by TREM-1. Significance: TREM-1 activation can propagate inflammation by modulating the survival of inflammatory cells.

Original language	English
Pages (from-to)	15118-15129
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	21
DOIs	https://doi.org/10.1074/jbc.M113.536490
State	Published - 2014

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title = "Triggering receptor expressed on myeloid cells 1 (TREM-1)- Mediated Bcl-2 induction prolongs macrophage survival",

abstract = "Background: Mechanisms by which triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammation are not fully defined. Results: TREM-1 induces anti-apoptotic protein Bcl-2. Conclusion: Macrophage survival is prolonged by TREM-1. Significance: TREM-1 activation can propagate inflammation by modulating the survival of inflammatory cells.",

author = "Zhihong Yuan and Syed, \{Mansoor Ali\} and Dipti Panchal and Myungsoo Joo and Marco Colonna and Mark Brantly and Sadikot, \{Ruxana T.\}",

year = "2014",

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AU - Yuan, Zhihong

AU - Syed, Mansoor Ali

AU - Panchal, Dipti

AU - Joo, Myungsoo

AU - Colonna, Marco

AU - Brantly, Mark

AU - Sadikot, Ruxana T.

PY - 2014

Y1 - 2014

N2 - Background: Mechanisms by which triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammation are not fully defined. Results: TREM-1 induces anti-apoptotic protein Bcl-2. Conclusion: Macrophage survival is prolonged by TREM-1. Significance: TREM-1 activation can propagate inflammation by modulating the survival of inflammatory cells.

AB - Background: Mechanisms by which triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammation are not fully defined. Results: TREM-1 induces anti-apoptotic protein Bcl-2. Conclusion: Macrophage survival is prolonged by TREM-1. Significance: TREM-1 activation can propagate inflammation by modulating the survival of inflammatory cells.

UR - https://www.scopus.com/pages/publications/84901406054

U2 - 10.1074/jbc.M113.536490

DO - 10.1074/jbc.M113.536490

M3 - Article

C2 - 24711453

AN - SCOPUS:84901406054

SN - 0021-9258

VL - 289

SP - 15118

EP - 15129

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 21

ER -

Triggering receptor expressed on myeloid cells 1 (TREM-1)- Mediated Bcl-2 induction prolongs macrophage survival

Abstract

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