Background: Mechanisms by which triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammation are not fully defined. Results: TREM-1 induces anti-apoptotic protein Bcl-2. Conclusion: Macrophage survival is prolonged by TREM-1. Significance: TREM-1 activation can propagate inflammation by modulating the survival of inflammatory cells.

Original languageEnglish
Pages (from-to)15118-15129
Number of pages12
JournalJournal of Biological Chemistry
Issue number21
StatePublished - 2014


Dive into the research topics of 'Triggering receptor expressed on myeloid cells 1 (TREM-1)- Mediated Bcl-2 induction prolongs macrophage survival'. Together they form a unique fingerprint.

Cite this