Triggering receptor expressed on myeloid cells 1 (TREM-1)- Mediated Bcl-2 induction prolongs macrophage survival

Zhihong Yuan, Mansoor Ali Syed, Dipti Panchal, Myungsoo Joo, Marco Colonna, Mark Brantly, Ruxana T. Sadikot

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Background: Mechanisms by which triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammation are not fully defined. Results: TREM-1 induces anti-apoptotic protein Bcl-2. Conclusion: Macrophage survival is prolonged by TREM-1. Significance: TREM-1 activation can propagate inflammation by modulating the survival of inflammatory cells.

Original languageEnglish
Pages (from-to)15118-15129
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number21
DOIs
StatePublished - Jan 1 2014

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