Trifluoromethylacetylenic Alcohols as Affinity Labels: Inactivation of Estradiol Dehydrogenase by a Trifluoromethylacetylenic Secoestradiol

Saurabh S. Lawate; Douglas F. Covey

doi:10.1021/jm00171a002

Trifluoromethylacetylenic Alcohols as Affinity Labels: Inactivation of Estradiol Dehydrogenase by a Trifluoromethylacetylenic Secoestradiol

Saurabh S. Lawate, Douglas F. Covey

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Abstract

Estradiol dehydrogenase (EC 1.1.1.62) is a pyridine-nucleotide-dependent enzyme that interconverts estradiol and estrone.¹ Because estradiol is more potent than estrone, this enzyme may serve to modulate estrogenic potency in vivo. Also, the role of the enzyme in reproductive endocrinology and in estrogen-dependent neoplasms is of widespread interest. Consequently, we have been involved in the development of inhibitors of estradiol dehydrogenase.

Original language	English
Pages (from-to)	2319-2321
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	33
Issue number	9
DOIs	https://doi.org/10.1021/jm00171a002
State	Published - 1990

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title = "Trifluoromethylacetylenic Alcohols as Affinity Labels: Inactivation of Estradiol Dehydrogenase by a Trifluoromethylacetylenic Secoestradiol",

abstract = "Estradiol dehydrogenase (EC 1.1.1.62) is a pyridine-nucleotide-dependent enzyme that interconverts estradiol and estrone.1 Because estradiol is more potent than estrone, this enzyme may serve to modulate estrogenic potency in vivo. Also, the role of the enzyme in reproductive endocrinology and in estrogen-dependent neoplasms is of widespread interest. Consequently, we have been involved in the development of inhibitors of estradiol dehydrogenase.",

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T2 - Inactivation of Estradiol Dehydrogenase by a Trifluoromethylacetylenic Secoestradiol

AU - Lawate, Saurabh S.

AU - Covey, Douglas F.

PY - 1990

Y1 - 1990

N2 - Estradiol dehydrogenase (EC 1.1.1.62) is a pyridine-nucleotide-dependent enzyme that interconverts estradiol and estrone.1 Because estradiol is more potent than estrone, this enzyme may serve to modulate estrogenic potency in vivo. Also, the role of the enzyme in reproductive endocrinology and in estrogen-dependent neoplasms is of widespread interest. Consequently, we have been involved in the development of inhibitors of estradiol dehydrogenase.

AB - Estradiol dehydrogenase (EC 1.1.1.62) is a pyridine-nucleotide-dependent enzyme that interconverts estradiol and estrone.1 Because estradiol is more potent than estrone, this enzyme may serve to modulate estrogenic potency in vivo. Also, the role of the enzyme in reproductive endocrinology and in estrogen-dependent neoplasms is of widespread interest. Consequently, we have been involved in the development of inhibitors of estradiol dehydrogenase.

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AN - SCOPUS:0025034471

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JO - Journal of Medicinal Chemistry

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ER -

Trifluoromethylacetylenic Alcohols as Affinity Labels: Inactivation of Estradiol Dehydrogenase by a Trifluoromethylacetylenic Secoestradiol

Abstract

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