Tricatecholamide analogs of enterobactin as gallium- and indium-binding radiopharmaceuticals

S. M. Moerlein, M. J. Welch, K. N. Raymond, F. L. Weitl

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Isopropyl N-substituted tricatecholamide analogs of enterobactin have been found to form gallium and indium complexes with very high stability constants and to exhibit in vivo characteristics significantly different from gallium- or indium-transferrin and EDTA. The 3,4-DiP-LICAMS and TiP-MECAMS complexes were found to clear primarily through the kidneys, whereas the less polar 3,4-DiP-LICAM complex was eliminated through the liver. The rationale for developing new metal-binding analogs with larger organic groups attached to the amide nitrogens is discussed.

Original languageEnglish
Pages (from-to)710-719
Number of pages10
JournalJournal of Nuclear Medicine
Issue number8
StatePublished - Jan 1 1981


Dive into the research topics of 'Tricatecholamide analogs of enterobactin as gallium- and indium-binding radiopharmaceuticals'. Together they form a unique fingerprint.

Cite this